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LIN28B

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GENERAL INFORMATION

Gene name

 LIN28B

Gene description

 Lin-28 homolog B (C. elegans)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus & nucleoli. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (BEWO, K-562, AF22)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported), Nucleoli (supported)

Additional location

 In addition localized to the Cytosol (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA061745
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, K-562, AF22)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus & nucleoli. In addition localized to the cytosol.

Main location

 Nucleus (supported), Nucleoli (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA061745 HEK 293 Nucleus
Nucleoli
Cytosol
HPA061745 Hep G2 Nucleus
Nucleoli
Cytosol
HPA061745 U-2 OS Nucleus

GENE INFORMATION

Gene name

 LIN28B (HGNC Symbol)

Synonyms

 CSDD2, FLJ16517

Description

 Lin-28 homolog B (C. elegans) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

Chromosome

 6

Cytoband

Chromosome location (bp)

 104957048 - 105083332

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187772 (version 83.38)

Entrez gene

 389421

UniProt

 Q6ZN17 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZN17

Antibodypedia

 LIN28B antibodies

PROTEIN BROWSER
LIN28B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIN28B-001
ENSP00000344401
ENST00000345080
Q6ZN17 [Direct mapping]
Protein lin-28 homolog B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010587 [miRNA catabolic process]
GO:0016235 [aggresome]
GO:0031054 [pre-miRNA processing]
GO:0031123 [RNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
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 250 aa
27.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.