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LIN28B

GENERAL INFORMATION

Gene name

 LIN28B

Gene description

 Lin-28 homolog B (C. elegans)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Cell line enhanced (AF22, BEWO, K-562)
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in subsets of cells in chorionic villi.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 2 antibodies.
HPA036630 , HPA061745
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036630
HPA061745

GENE INFORMATION

Gene name

 LIN28B (HGNC Symbol)

Synonyms

 CSDD2, FLJ16517

Description

 Lin-28 homolog B (C. elegans) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

Chromosome

 6

Cytoband

Chromosome location (bp)

 104957048 - 105083332

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000187772 (version 83.38)

Entrez gene

 389421

UniProt

 Q6ZN17 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZN17

Antibodypedia

 LIN28B antibodies

PROTEIN BROWSER
LIN28B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIN28B-001
ENSP00000344401
ENST00000345080
Q6ZN17 [Direct mapping]
Protein lin-28 homolog B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0010587 [miRNA catabolic process]
GO:0016235 [aggresome]
GO:0031054 [pre-miRNA processing]
GO:0031123 [RNA 3'-end processing]
GO:0044822 [poly(A) RNA binding]
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 250 aa
27.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.