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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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NOC2L
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

NOC2L

Gene description

NOC2-like nucleolar associated transcriptional repressor

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nucleolar and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA044258
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA044258

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed weak to moderate nucleolar andcytoplasmic positivity. Few melanomas, testicular and pancreatic cancers along with a rare case of cholangiocarcinoma, malignant lymphoma and colon cancer displayed strong immunoreactivity. Carcinoids, gliomas, urothelial, liver, renal and endometrial cancers were mainly negative.

GENE INFORMATION

Gene name

NOC2L (HGNC Symbol)

Synonyms

DKFZP564C186, NET15, NET7, NIR, PPP1R112

Description

NOC2-like nucleolar associated transcriptional repressor (HGNC Symbol)

Entrez gene summary

Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

Chromosome

1

Cytoband

p36.33

Chromosome location (bp)

944204 - 959309

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000188976 (version 83.38)

Entrez gene

26155

UniProt

Q9Y3T9 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y3T9

Antibodypedia

NOC2L antibodies

PROTEIN BROWSER

NOC2L-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOC2L-001
ENSP00000317992
ENST00000327044
Q9Y3T9 [Direct mapping]
Nucleolar complex protein 2 homolog
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   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002903 [negative regulation of B cell apoptotic process]
GO:0003682 [chromatin binding]
GO:0003714 [transcription corepressor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0031491 [nucleosome binding]
GO:0031497 [chromatin assembly]
GO:0032066 [nucleolus to nucleoplasm transport]
GO:0034644 [cellular response to UV]
GO:0035067 [negative regulation of histone acetylation]
GO:0042393 [histone binding]
GO:0044822 [poly(A) RNA binding]
GO:0070491 [repressing transcription factor binding]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
Show all
749 aa
84.9 kDa
No 0

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