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HMGB1

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GENERAL INFORMATION

Gene name

 HMGB1

Gene description

 High mobility group box 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
CAB005873
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB005873 A-431 Nucleus Intensity
CAB005873 U-2 OS Nucleus
CAB005873 U-251 MG Nucleus

GENE INFORMATION

Gene name

 HMGB1 (HGNC Symbol)

Synonyms

 DKFZp686A04236, HMG1, HMG3, SBP-1

Description

 High mobility group box 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

Chromosome

 13

Cytoband

 q12.3

Chromosome location (bp)

 30456704 - 30617597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189403 (version 83.38)

Entrez gene

 3146

UniProt

 P09429 (UniProt - Evidence at protein level)

neXtProt

 NX_P09429

Antibodypedia

 HMGB1 antibodies

PROTEIN BROWSER
HMGB1-001
HMGB1-003
HMGB1-004
HMGB1-009
HMGB1-011
HMGB1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGB1-001
ENSP00000343040
ENST00000339872
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:1990774 [tumor necrosis factor secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-003
ENSP00000369904
ENST00000326004
Q5T7C4 [Direct mapping]
High mobility group protein B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005125 [cytokine activity]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006954 [inflammatory response]
Show all
 158 aa
18.3 kDa 		No 0
HMGB1-004
ENSP00000345347
ENST00000341423
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001935 [endothelial cell proliferation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002270 [plasmacytoid dendritic cell activation]
GO:0002281 [macrophage activation involved in immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005769 [early endosome]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006284 [base-excision repair]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0031497 [chromatin assembly]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033151 [V(D)J recombination]
GO:0034137 [positive regulation of toll-like receptor 2 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0035767 [endothelial cell chemotaxis]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0090303 [positive regulation of wound healing]
GO:0097100 [supercoiled DNA binding]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1990774 [tumor necrosis factor secretion]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2000778 [positive regulation of interleukin-6 secretion]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-009
ENSP00000382412
ENST00000399489
Q5T7C4 [Direct mapping]
High mobility group protein B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005125 [cytokine activity]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006954 [inflammatory response]
Show all
 158 aa
18.3 kDa 		No 0
HMGB1-011
ENSP00000382417
ENST00000399494
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:1990774 [tumor necrosis factor secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-012
ENSP00000384678
ENST00000405805
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:1990774 [tumor necrosis factor secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 215 aa
24.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.