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HMGB1

GENERAL INFORMATION

Gene name

 HMGB1

Gene description

 High mobility group box 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA003506 , CAB005873
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all
0.020406080100120140FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA003506
CAB005873

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Cancer cells showed moderate to strong nuclear immunoreactivity. Stroma and inflammatory cells were also positive.

GENE INFORMATION

Gene name

 HMGB1 (HGNC Symbol)

Synonyms

 DKFZp686A04236, HMG1, HMG3, SBP-1

Description

 High mobility group box 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

Chromosome

 13

Cytoband

 q12.3

Chromosome location (bp)

 30456704 - 30617597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000189403 (version 83.38)

Entrez gene

 3146

UniProt

 P09429 (UniProt - Evidence at protein level)

neXtProt

 NX_P09429

Antibodypedia

 HMGB1 antibodies

PROTEIN BROWSER
HMGB1-001
HMGB1-003
HMGB1-004
HMGB1-009
HMGB1-011
HMGB1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HMGB1-001
ENSP00000343040
ENST00000339872
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:1990774 [tumor necrosis factor secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-003
ENSP00000369904
ENST00000326004
Q5T7C4 [Direct mapping]
High mobility group protein B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005125 [cytokine activity]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006954 [inflammatory response]
Show all
 158 aa
18.3 kDa 		No 0
HMGB1-004
ENSP00000345347
ENST00000341423
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0001935 [endothelial cell proliferation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002270 [plasmacytoid dendritic cell activation]
GO:0002281 [macrophage activation involved in immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0003727 [single-stranded RNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005769 [early endosome]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006284 [base-excision repair]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0031497 [chromatin assembly]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032760 [positive regulation of tumor necrosis factor production]
GO:0033151 [V(D)J recombination]
GO:0034137 [positive regulation of toll-like receptor 2 signaling pathway]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0035767 [endothelial cell chemotaxis]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045089 [positive regulation of innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0090303 [positive regulation of wound healing]
GO:0097100 [supercoiled DNA binding]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1903672 [positive regulation of sprouting angiogenesis]
GO:1990774 [tumor necrosis factor secretion]
GO:2000426 [negative regulation of apoptotic cell clearance]
GO:2000778 [positive regulation of interleukin-6 secretion]
GO:2000819 [regulation of nucleotide-excision repair]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-009
ENSP00000382412
ENST00000399489
Q5T7C4 [Direct mapping]
High mobility group protein B1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005125 [cytokine activity]
GO:0005634 [nucleus]
GO:0006338 [chromatin remodeling]
GO:0006954 [inflammatory response]
Show all
 158 aa
18.3 kDa 		No 0
HMGB1-011
ENSP00000382417
ENST00000399494
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:1990774 [tumor necrosis factor secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 215 aa
24.9 kDa 		No 0
HMGB1-012
ENSP00000384678
ENST00000405805
P09429 [Direct mapping]
High mobility group protein B1
A0A024RDR0 [Target identity:100%; Query identity:100%]
High-mobility group box 1, isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000400 [four-way junction DNA binding]
GO:0000405 [bubble DNA binding]
GO:0000793 [condensed chromosome]
GO:0001530 [lipopolysaccharide binding]
GO:0001773 [myeloid dendritic cell activation]
GO:0002218 [activation of innate immune response]
GO:0002250 [adaptive immune response]
GO:0002407 [dendritic cell chemotaxis]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0002643 [regulation of tolerance induction]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005125 [cytokine activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005793 [endoplasmic reticulum-Golgi intermediate compartment]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006265 [DNA topological change]
GO:0006309 [apoptotic DNA fragmentation]
GO:0006310 [DNA recombination]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006914 [autophagy]
GO:0006915 [apoptotic process]
GO:0006921 [cellular component disassembly involved in execution phase of apoptosis]
GO:0006954 [inflammatory response]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0008134 [transcription factor binding]
GO:0008301 [DNA binding, bending]
GO:0009986 [cell surface]
GO:0010506 [regulation of autophagy]
GO:0012501 [programmed cell death]
GO:0016829 [lyase activity]
GO:0017053 [transcriptional repressor complex]
GO:0017055 [negative regulation of RNA polymerase II transcriptional preinitiation complex assembly]
GO:0019958 [C-X-C chemokine binding]
GO:0031175 [neuron projection development]
GO:0032072 [regulation of restriction endodeoxyribonuclease activity]
GO:0032392 [DNA geometric change]
GO:0032425 [positive regulation of mismatch repair]
GO:0033151 [V(D)J recombination]
GO:0042056 [chemoattractant activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043388 [positive regulation of DNA binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0043537 [negative regulation of blood vessel endothelial cell migration]
GO:0044822 [poly(A) RNA binding]
GO:0045087 [innate immune response]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046330 [positive regulation of JNK cascade]
GO:0050716 [positive regulation of interleukin-1 secretion]
GO:0050786 [RAGE receptor binding]
GO:0050918 [positive chemotaxis]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0070182 [DNA polymerase binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070491 [repressing transcription factor binding]
GO:0090026 [positive regulation of monocyte chemotaxis]
GO:0097100 [supercoiled DNA binding]
GO:1990774 [tumor necrosis factor secretion]
GO:2000778 [positive regulation of interleukin-6 secretion]
Show all
 215 aa
24.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.