Cell atlas - SYCP2 - The Human Protein Atlas

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SYCP2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SYCP2
Gene description	Synaptonemal complex protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.
RNA cell category	Cell line enhanced (SiHa, T-47d, MOLT-4)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Plasma membrane (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA062401 , HPA065613
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SiHa, T-47d, MOLT-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the plasma membrane & cytosol.

Main location

Nucleoplasm (supported)

Additional location

Plasma membrane (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA062401	CACO-2	Nucleoplasm
	HPA062401	CACO-2	Plasma membrane
	HPA062401	SiHa	Nucleoplasm
	HPA062401	SiHa	Cytosol
	HPA062401	U-2 OS	Nucleoplasm
	HPA062401	U-2 OS	Cytosol
	HPA065613	CACO-2	Nucleoplasm
	HPA065613	SiHa	Nucleoplasm
	HPA065613	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	SYCP2 (HGNC Symbol)
Synonyms	SCP2
Description	Synaptonemal complex protein 2 (HGNC Symbol)
Entrez gene summary	The synaptonemal complex is a proteinaceous structure that links homologous chromosomes during the prophase of meiosis. The protein encoded by this gene is a major component of the synaptonemal complex and may bind DNA at scaffold attachment regions. The encoded protein requires synaptonemal complex protein 3, but not 1, for inclusion in the synaptonemal complex. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.33
Chromosome location (bp)	59863563 - 59933655
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196074 (version 83.38)
Entrez gene	10388
UniProt	Q9BX26 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9BX26
Antibodypedia	SYCP2 antibodies

PROTEIN BROWSER

SYCP2-001	SYCP2-002	SYCP2-003	SYCP2-008	SYCP2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SYCP2-001 ENSP00000350162 ENST00000357552	Q9BX26 [Direct mapping] Synaptonemal complex protein 2 Show all	Predicted intracellular proteins Show all	GO:0000795 [synaptonemal complex] GO:0000800 [lateral element] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0007130 [synaptonemal complex assembly] GO:0007140 [male meiosis] GO:0007143 [female meiotic division] GO:0009566 [fertilization] GO:0009887 [organ morphogenesis] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0048808 [male genitalia morphogenesis] GO:0051301 [cell division] Show all	1530 aa 175.6 kDa	No	0
SYCP2-002 ENSP00000402456 ENST00000446834	A2A341 [Direct mapping] Synaptonemal complex protein 2 Show all	Predicted intracellular proteins Show all		1023 aa 116.5 kDa	No	0
SYCP2-003 ENSP00000399300 ENST00000425931	A2A2M9 [Direct mapping] Synaptonemal complex protein 2 Show all	Predicted intracellular proteins Show all		118 aa 13.4 kDa	No	0
SYCP2-008 ENSP00000404358 ENST00000412613	A2A340 [Direct mapping] Synaptonemal complex protein 2 Show all	Predicted intracellular proteins Show all		208 aa 25.1 kDa	No	0
SYCP2-201 ENSP00000360040 ENST00000371001	Q9BX26 [Direct mapping] Synaptonemal complex protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0000795 [synaptonemal complex] GO:0003677 [DNA binding] GO:0005634 [nucleus] GO:0007130 [synaptonemal complex assembly] GO:0051301 [cell division] Show all	1530 aa 175.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.