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Mainly localized to the nucleus & cytosol. In addition localized to the endoplasmic reticulum & nucleoli (fibrillar center).
Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category
Cell line enhanced (A549, Hep G2, RT4)
Protein evidence
Evidence at protein level
Main location
Localized to the Nucleus (approved), Cytosol (approved)
Additional location
In addition localized to the Nucleoli fibrillar center (approved), Endoplasmic reticulum (approved)
Single-cell variation
Single-cell variation in protein expression observed.
RNA cell line category: Cell line enhanced (A549, Hep G2, RT4)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
HUMAN CELLS
Summary
Mainly localized to the nucleus & cytosol. In addition localized to the endoplasmic reticulum & nucleoli (fibrillar center).
Caution: Based on antibodies targeting proteins from multiple genes.
Main location
Nucleus (approved), Cytosol (approved)
Additional location
Nucleoli fibrillar center (approved), Endoplasmic reticulum (approved)
Aldo-keto reductase family 1, member C3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
P42330 [Direct mapping] Aldo-keto reductase family 1 member C3
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Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
S4R3Z2 [Direct mapping] Aldo-keto reductase family 1 member C3; Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), isoform CRA_a
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)