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AKR1C3

GENERAL INFORMATION

Gene name

 AKR1C3

Gene description

 Aldo-keto reductase family 1, member C3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic with cases of nuclear expression in several tissues, most abundant in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB010874
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 AKR1C3 (HGNC Symbol)

Synonyms

 DDX, HAKRB, HSD17B5, KIAA0119, PGFS

Description

 Aldo-keto reductase family 1, member C3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Chromosome

 10

Cytoband

 p15.1

Chromosome location (bp)

 5035354 - 5107686

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196139 (version 83.38)

Entrez gene

 8644

UniProt

 P42330 (UniProt - Evidence at protein level)

neXtProt

 NX_P42330

Antibodypedia

 AKR1C3 antibodies

PROTEIN BROWSER
AKR1C3-001
AKR1C3-006
AKR1C3-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKR1C3-001
ENSP00000369927
ENST00000380554
P42330 [Direct mapping]
Aldo-keto reductase family 1 member C3
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Enzymes
   ENZYME proteins
   Oxidoreductases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000060 [protein import into nucleus, translocation]
GO:0001523 [retinoid metabolic process]
GO:0001758 [retinal dehydrogenase activity]
GO:0004032 [alditol:NADP+ 1-oxidoreductase activity]
GO:0004033 [aldo-keto reductase (NADP) activity]
GO:0004745 [retinol dehydrogenase activity]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006693 [prostaglandin metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007584 [response to nutrient]
GO:0007603 [phototransduction, visible light]
GO:0008202 [steroid metabolic process]
GO:0008284 [positive regulation of cell proliferation]
GO:0008584 [male gonad development]
GO:0009267 [cellular response to starvation]
GO:0010942 [positive regulation of cell death]
GO:0016488 [farnesol catabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016655 [oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor]
GO:0018636 [phenanthrene 9,10-monooxygenase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0019371 [cyclooxygenase pathway]
GO:0030216 [keratinocyte differentiation]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035410 [dihydrotestosterone 17-beta-dehydrogenase activity]
GO:0036131 [prostaglandin D2 11-ketoreductase activity]
GO:0042448 [progesterone metabolic process]
GO:0042574 [retinal metabolic process]
GO:0044259 [multicellular organismal macromolecule metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0045550 [geranylgeranyl reductase activity]
GO:0045703 [ketoreductase activity]
GO:0047017 [prostaglandin-F synthase activity]
GO:0047020 [15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity]
GO:0047023 [androsterone dehydrogenase activity]
GO:0047035 [testosterone dehydrogenase (NAD+) activity]
GO:0047045 [testosterone 17-beta-dehydrogenase (NADP+) activity]
GO:0047086 [ketosteroid monooxygenase activity]
GO:0047115 [trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity]
GO:0047718 [indanol dehydrogenase activity]
GO:0047787 [delta4-3-oxosteroid 5beta-reductase activity]
GO:0048385 [regulation of retinoic acid receptor signaling pathway]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0055114 [oxidation-reduction process]
GO:0061370 [testosterone biosynthetic process]
GO:0070062 [extracellular exosome]
GO:0070293 [renal absorption]
GO:0071276 [cellular response to cadmium ion]
GO:0071277 [cellular response to calcium ion]
GO:0071379 [cellular response to prostaglandin stimulus]
GO:0071384 [cellular response to corticosteroid stimulus]
GO:0071395 [cellular response to jasmonic acid stimulus]
GO:0071799 [cellular response to prostaglandin D stimulus]
GO:1900053 [negative regulation of retinoic acid biosynthetic process]
GO:2000224 [regulation of testosterone biosynthetic process]
GO:2000353 [positive regulation of endothelial cell apoptotic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
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 323 aa
36.9 kDa 		No 0
AKR1C3-006
ENSP00000474882
ENST00000605149
S4R3Z2 [Direct mapping]
Aldo-keto reductase family 1 member C3; Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 300 aa
34.3 kDa 		No 0
AKR1C3-008
ENSP00000474188
ENST00000602997
S4R3D5 [Direct mapping]
Aldo-keto reductase family 1 member C3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
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 155 aa
17.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.