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Cancer tissues showed distinct nuclear and cytoplasmic staining in fractions of cases while the remaining cases were negative. Distinct immunoreactivity was for example observed in most gliomas, liver and urothelial cancers. Melanomas, skin and testicular cancers were negative.
GENE INFORMATION
Gene name
AKR1C3 (HGNC Symbol)
Synonyms
DDX, HAKRB, HSD17B5, KIAA0119, PGFS
Description
Aldo-keto reductase family 1, member C3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
P42330 [Direct mapping] Aldo-keto reductase family 1 member C3
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Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
S4R3Z2 [Direct mapping] Aldo-keto reductase family 1 member C3; Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), isoform CRA_a
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Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)