Cell atlas - AFAP1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	AFAP1
Gene description	Actin filament associated protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the actin filaments & focal adhesion sites. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Actin filaments (supported), Focal adhesion sites (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA015642
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the actin filaments & focal adhesion sites. In addition localized to the cytosol.

Main location

Actin filaments (supported), Focal adhesion sites (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA015642	A-431	Actin filaments
HPA015642	A-431	Cytosol
HPA015642	U-2 OS	Actin filaments
HPA015642	U-2 OS	Cytosol
HPA015642	U-251 MG	Actin filaments
		Focal adhesion sites
		Cytosol

GENE INFORMATION
Gene name	AFAP1 (HGNC Symbol)
Synonyms	AFAP, AFAP-110
Description	Actin filament associated protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	7758714 - 7939926
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196526 (version 83.38)
Entrez gene	60312
UniProt	Q8N556 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N556
Antibodypedia	AFAP1 antibodies

PROTEIN BROWSER

AFAP1-001	AFAP1-002	AFAP1-008	AFAP1-201	AFAP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AFAP1-001 ENSP00000353402 ENST00000360265	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	730 aa 80.7 kDa	No	0
AFAP1-002 ENSP00000371983 ENST00000382543	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	814 aa 89.8 kDa	No	0
AFAP1-008 ENSP00000483962 ENST00000614385	A0A087X177 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009966 [regulation of signal transduction] GO:0051493 [regulation of cytoskeleton organization] Show all	92 aa 9.7 kDa	No	0
AFAP1-201 ENSP00000351245 ENST00000358461	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	730 aa 80.7 kDa	No	0
AFAP1-202 ENSP00000410689 ENST00000420658	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	814 aa 89.8 kDa	No	0