Expression of AFAP1 in cancer - Summary - The Human Protein Atlas

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AFAP1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AFAP1
Gene description	Actin filament associated protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression which a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA015642 , CAB024712
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable) and renal cancer (unfavourable).
Lung cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015642	CAB024712

GENE INFORMATION
Gene name	AFAP1 (HGNC Symbol)
Synonyms	AFAP, AFAP-110
Description	Actin filament associated protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	7758714 - 7939926
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196526 (version 83.38)
Entrez gene	60312
UniProt	Q8N556 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N556
Antibodypedia	AFAP1 antibodies

PROTEIN BROWSER

AFAP1-001	AFAP1-002	AFAP1-008	AFAP1-201	AFAP1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AFAP1-001 ENSP00000353402 ENST00000360265	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	730 aa 80.7 kDa	No	0
AFAP1-002 ENSP00000371983 ENST00000382543	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	814 aa 89.8 kDa	No	0
AFAP1-008 ENSP00000483962 ENST00000614385	A0A087X177 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0009966 [regulation of signal transduction] GO:0051493 [regulation of cytoskeleton organization] Show all	92 aa 9.7 kDa	No	0
AFAP1-201 ENSP00000351245 ENST00000358461	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	730 aa 80.7 kDa	No	0
AFAP1-202 ENSP00000410689 ENST00000420658	Q8N556 [Direct mapping] Actin filament-associated protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] GO:0009966 [regulation of signal transduction] GO:0015629 [actin cytoskeleton] GO:0051493 [regulation of cytoskeleton organization] Show all	814 aa 89.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.