Expression of CD47 in cancer - Summary - The Human Protein Atlas

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CD47

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD47
Gene description	CD47 molecule
Protein class	CD markers Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA044659 , CAB016055
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable), renal cancer (unfavourable) and endometrial cancer (unfavourable).
Thyroid cancer p<0.001 Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA044659	CAB016055

GENE INFORMATION
Gene name	CD47 (HGNC Symbol)
Synonyms	IAP, MER6, OA3
Description	CD47 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Chromosome	3
Cytoband	q13.12
Chromosome location (bp)	108043298 - 108091025
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196776 (version 83.38)
Entrez gene	961
UniProt	Q08722 (UniProt - Evidence at protein level)
neXtProt	NX_Q08722
Antibodypedia	CD47 antibodies

PROTEIN BROWSER

CD47-001	CD47-002	CD47-004	CD47-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD47-001 ENSP00000381309 ENST00000398258	H7BYS8 [Direct mapping] Leukocyte surface antigen CD47 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.9 kDa	No	0
CD47-002 ENSP00000347512 ENST00000355354	Q08722 [Direct mapping] Leukocyte surface antigen CD47 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0022409 [positive regulation of cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] GO:0070053 [thrombospondin receptor activity] GO:0070062 [extracellular exosome] Show all	305 aa 33.2 kDa	Yes	5
CD47-004 ENSP00000355361 ENST00000361309	Q08722 [Direct mapping] Leukocyte surface antigen CD47 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008228 [opsonization] GO:0008284 [positive regulation of cell proliferation] GO:0009617 [response to bacterium] GO:0022409 [positive regulation of cell-cell adhesion] GO:0030198 [extracellular matrix organization] GO:0050729 [positive regulation of inflammatory response] GO:0050766 [positive regulation of phagocytosis] GO:0050870 [positive regulation of T cell activation] GO:0050900 [leukocyte migration] GO:0070053 [thrombospondin receptor activity] GO:0070062 [extracellular exosome] Show all	323 aa 35.2 kDa	Yes	6
CD47-005 ENSP00000430843 ENST00000517766	H0YC40 [Direct mapping] Leukocyte surface antigen CD47 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	109 aa 11.4 kDa	No	4

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.