Cancer cells showed weak cytoplasmic staining or were generally negative. Several cases of ovarian and urothelial cancers were moderately stained.
CD47 (HGNC Symbol)
IAP, MER6, OA3
CD47 molecule (HGNC Symbol)
Entrez gene summary
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]