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CD47

GENERAL INFORMATION

Gene name

 CD47

Gene description

 CD47 molecule

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA044659 , CAB016055
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Prostate

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CD47 (HGNC Symbol)

Synonyms

 IAP, MER6, OA3

Description

 CD47 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Chromosome

 3

Cytoband

 q13.12

Chromosome location (bp)

 108043298 - 108091025

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196776 (version 83.38)

Entrez gene

 961

UniProt

 Q08722 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08722

Antibodypedia

 CD47 antibodies

PROTEIN BROWSER
CD47-001
CD47-002
CD47-004
CD47-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD47-001
ENSP00000381309
ENST00000398258
H7BYS8 [Direct mapping]
Leukocyte surface antigen CD47
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 86 aa
9.9 kDa 		No 0
CD47-002
ENSP00000347512
ENST00000355354
Q08722 [Direct mapping]
Leukocyte surface antigen CD47
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030198 [extracellular matrix organization]
GO:0050870 [positive regulation of T cell activation]
GO:0050900 [leukocyte migration]
GO:0070053 [thrombospondin receptor activity]
GO:0070062 [extracellular exosome]
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 305 aa
33.2 kDa 		Yes 5
CD47-004
ENSP00000355361
ENST00000361309
Q08722 [Direct mapping]
Leukocyte surface antigen CD47
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007596 [blood coagulation]
GO:0008228 [opsonization]
GO:0008284 [positive regulation of cell proliferation]
GO:0009617 [response to bacterium]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030198 [extracellular matrix organization]
GO:0050729 [positive regulation of inflammatory response]
GO:0050766 [positive regulation of phagocytosis]
GO:0050870 [positive regulation of T cell activation]
GO:0050900 [leukocyte migration]
GO:0070053 [thrombospondin receptor activity]
GO:0070062 [extracellular exosome]
Show all
 323 aa
35.2 kDa 		Yes 6
CD47-005
ENSP00000430843
ENST00000517766
H0YC40 [Direct mapping]
Leukocyte surface antigen CD47
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 109 aa
11.4 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.