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ARID5A

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GENERAL INFORMATION

Gene name

 ARID5A

Gene description

 AT rich interactive domain 5A (MRF1-like)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

RNA cell category

 Group enriched (HDLM-2, RPMI-8226)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

Additional location

 In addition localized to the Nucleoli (supported)

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA002860 , HPA023879
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (HDLM-2, RPMI-8226)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the nucleoli.

Main location

 Nucleus (validated)

Additional location

 Nucleoli (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA023879 A-431 Nucleus
Nucleoli
HPA023879 U-2 OS Nucleus
Nucleoli
HPA023879 U-251 MG Nucleus
Nucleoli
HPA002860 A-431 Nucleoplasm
HPA002860 U-2 OS Nucleoplasm
HPA002860 U-251 MG Nucleoplasm

GENE INFORMATION

Gene name

 ARID5A (HGNC Symbol)

Synonyms

 MRF-1, RP11-363D14

Description

 AT rich interactive domain 5A (MRF1-like) (HGNC Symbol)

Entrez gene summary

 Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 96536743 - 96552638

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196843 (version 83.38)

Entrez gene

 10865

UniProt

 Q03989 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03989

Antibodypedia

 ARID5A antibodies

PROTEIN BROWSER
ARID5A-001
ARID5A-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARID5A-001
ENSP00000350078
ENST00000357485
Q03989 [Direct mapping]
AT-rich interactive domain-containing protein 5A
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 594 aa
64.1 kDa 		No 0
ARID5A-004
ENSP00000400785
ENST00000454558
C9J1Q0 [Direct mapping]
AT rich interactive domain 5A (MRF1-like), isoform CRA_a; AT-rich interactive domain-containing protein 5A
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Predicted intracellular proteins
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0044212 [transcription regulatory region DNA binding]
Show all
 526 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.