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ARID5A

GENERAL INFORMATION

Gene name

 ARID5A

Gene description

 AT rich interactive domain 5A (MRF1-like)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Group enriched (HDLM-2, RPMI-8226)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in most tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA023879
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA023879

GENE INFORMATION

Gene name

 ARID5A (HGNC Symbol)

Synonyms

 MRF-1, RP11-363D14

Description

 AT rich interactive domain 5A (MRF1-like) (HGNC Symbol)

Entrez gene summary

 Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 96536743 - 96552638

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196843 (version 83.38)

Entrez gene

 10865

UniProt

 Q03989 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03989

Antibodypedia

 ARID5A antibodies

PROTEIN BROWSER
ARID5A-001
ARID5A-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARID5A-001
ENSP00000350078
ENST00000357485
Q03989 [Direct mapping]
AT-rich interactive domain-containing protein 5A
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0008134 [transcription factor binding]
GO:0035066 [positive regulation of histone acetylation]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 594 aa
64.1 kDa 		No 0
ARID5A-004
ENSP00000400785
ENST00000454558
C9J1Q0 [Direct mapping]
AT rich interactive domain 5A (MRF1-like), isoform CRA_a; AT-rich interactive domain-containing protein 5A
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0044212 [transcription regulatory region DNA binding]
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 526 aa
56.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.