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Moderate to strong cytoplasmic and membranous immunoreactivity was observed in some testicular cancers, malignant lymphomas, cervical cancers and colorectal cancers. Remaining tumors were in general negative. Tumor stroma and muscular tissue was distinctly stained.
The staining intensity was correlated to tumor cell differentiation. Where differentiation was lost, the staining intensity increased. In brain tumors low grade astrocytomas were almost unstained, whereas highly malignant glioblastomas were strongly stained.
Most cancers showed moderate to strong cytoplasmic positivity. Prostate, colorectal, gastric ad liver cancers were mainly negative. Cancer stroma was positive.
GENE INFORMATION
Gene name
FLNA (HGNC Symbol)
Synonyms
ABP-280, FLN, FLN1, OPD1, OPD2
Description
Filamin A, alpha (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]
Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)