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FLNA

GENERAL INFORMATION

Gene name

 FLNA

Gene description

 Filamin A, alpha

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic expression in smooth muscle, myoepithelia, squamous epithelia and subsets of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 3 antibodies.
HPA001115 , HPA002925 , CAB000356
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 FLNA (HGNC Symbol)

Synonyms

 ABP-280, FLN, FLN1, OPD1, OPD2

Description

 Filamin A, alpha (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 154348524 - 154374638

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196924 (version 83.38)

Entrez gene

 2316

UniProt

 P21333 (UniProt - Evidence at protein level)

neXtProt

 NX_P21333

Antibodypedia

 FLNA antibodies

PROTEIN BROWSER
FLNA-001
FLNA-002
FLNA-010
FLNA-015
FLNA-016
FLNA-022
FLNA-201
FLNA-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLNA-001
ENSP00000353467
ENST00000360319
P21333 [Direct mapping]
Filamin-A
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0002576 [platelet degranulation]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016479 [negative regulation of transcription from RNA polymerase I promoter]
GO:0017048 [Rho GTPase binding]
GO:0017160 [Ral GTPase binding]
GO:0030168 [platelet activation]
GO:0031267 [small GTPase binding]
GO:0031523 [Myb complex]
GO:0031532 [actin cytoskeleton reorganization]
GO:0034329 [cell junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042384 [cilium assembly]
GO:0042803 [protein homodimerization activity]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043113 [receptor clustering]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0048365 [Rac GTPase binding]
GO:0050821 [protein stabilization]
GO:0051015 [actin filament binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0090307 [mitotic spindle assembly]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 2639 aa
280 kDa 		No 0
FLNA-002
ENSP00000358866
ENST00000369850
P21333 [Direct mapping]
Filamin-A
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001837 [epithelial to mesenchymal transition]
GO:0001948 [glycoprotein binding]
GO:0002576 [platelet degranulation]
GO:0004871 [signal transducer activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005802 [trans-Golgi network]
GO:0005829 [cytosol]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016479 [negative regulation of transcription from RNA polymerase I promoter]
GO:0017048 [Rho GTPase binding]
GO:0017160 [Ral GTPase binding]
GO:0030036 [actin cytoskeleton organization]
GO:0030168 [platelet activation]
GO:0030863 [cortical cytoskeleton]
GO:0031267 [small GTPase binding]
GO:0031523 [Myb complex]
GO:0031532 [actin cytoskeleton reorganization]
GO:0031852 [mu-type opioid receptor binding]
GO:0032403 [protein complex binding]
GO:0032432 [actin filament bundle]
GO:0034329 [cell junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042384 [cilium assembly]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0042803 [protein homodimerization activity]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043025 [neuronal cell body]
GO:0043066 [negative regulation of apoptotic process]
GO:0043113 [receptor clustering]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043198 [dendritic shaft]
GO:0043234 [protein complex]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044822 [poly(A) RNA binding]
GO:0045022 [early endosome to late endosome transport]
GO:0045184 [establishment of protein localization]
GO:0046332 [SMAD binding]
GO:0048365 [Rac GTPase binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050821 [protein stabilization]
GO:0051015 [actin filament binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0090307 [mitotic spindle assembly]
GO:0097440 [apical dendrite]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 2647 aa
280.7 kDa 		No 0
FLNA-010
ENSP00000358863
ENST00000344736
Q5HY54 [Direct mapping]
Filamin-A
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015629 [actin cytoskeleton]
GO:0051015 [actin filament binding]
Show all
 2607 aa
276.5 kDa 		No 0
FLNA-015
ENSP00000398215
ENST00000438732
H0Y5F3 [Direct mapping]
Filamin-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
Show all
 232 aa
25 kDa 		No 0
FLNA-016
ENSP00000397824
ENST00000444578
H0Y5C6 [Direct mapping]
Filamin-A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
Show all
 281 aa
29.9 kDa 		No 0
FLNA-022
ENSP00000358872
ENST00000369856
Q60FE5 [Direct mapping]
Filamin A; Filamin-A
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0015629 [actin cytoskeleton]
Show all
 2620 aa
278.2 kDa 		No 0
FLNA-201
ENSP00000416926
ENST00000422373
P21333 [Direct mapping]
Filamin-A
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001948 [glycoprotein binding]
GO:0002576 [platelet degranulation]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0007195 [adenylate cyclase-inhibiting dopamine receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007596 [blood coagulation]
GO:0008134 [transcription factor binding]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0016479 [negative regulation of transcription from RNA polymerase I promoter]
GO:0017048 [Rho GTPase binding]
GO:0017160 [Ral GTPase binding]
GO:0030168 [platelet activation]
GO:0031267 [small GTPase binding]
GO:0031523 [Myb complex]
GO:0031532 [actin cytoskeleton reorganization]
GO:0034329 [cell junction assembly]
GO:0034394 [protein localization to cell surface]
GO:0034988 [Fc-gamma receptor I complex binding]
GO:0042177 [negative regulation of protein catabolic process]
GO:0042384 [cilium assembly]
GO:0042803 [protein homodimerization activity]
GO:0042993 [positive regulation of transcription factor import into nucleus]
GO:0043066 [negative regulation of apoptotic process]
GO:0043113 [receptor clustering]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0044822 [poly(A) RNA binding]
GO:0045184 [establishment of protein localization]
GO:0048365 [Rac GTPase binding]
GO:0050821 [protein stabilization]
GO:0051015 [actin filament binding]
GO:0051220 [cytoplasmic sequestering of protein]
GO:0051764 [actin crosslink formation]
GO:0070062 [extracellular exosome]
GO:0070527 [platelet aggregation]
GO:0090307 [mitotic spindle assembly]
GO:1900026 [positive regulation of substrate adhesion-dependent cell spreading]
GO:2001046 [positive regulation of integrin-mediated signaling pathway]
Show all
 2639 aa
280 kDa 		No 0
FLNA-202
ENSP00000480593
ENST00000610817
A0A087WWY3 [Direct mapping]
Filamin-A
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051015 [actin filament binding]
Show all
 2315 aa
245.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.