Cell atlas - CASP4 - The Human Protein Atlas

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CASP4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CASP4
Gene description	Caspase 4, apoptosis-related cysteine peptidase
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA027588
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

Cytosol (approved)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027588	A-431	Plasma membrane
	HPA027588	A-431	Cytosol
	HPA027588	U-2 OS	Plasma membrane
	HPA027588	U-2 OS	Cytosol
	HPA027588	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CASP4 (HGNC Symbol)
Synonyms	ICE(rel)II, ICH-2, TX
Description	Caspase 4, apoptosis-related cysteine peptidase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q22.3
Chromosome location (bp)	104942866 - 104969436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196954 (version 83.38)
Entrez gene	837
UniProt	P49662 (UniProt - Evidence at protein level)
neXtProt	NX_P49662
Antibodypedia	CASP4 antibodies

PROTEIN BROWSER

CASP4-001	CASP4-004	CASP4-007	CASP4-013	CASP4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASP4-001 ENSP00000388566 ENST00000444739	P49662 [Direct mapping] Caspase-4 Caspase-4 subunit 1 Caspase-4 subunit 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0042981 [regulation of apoptotic process] GO:0050727 [regulation of inflammatory response] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	377 aa 43.3 kDa	No	0
CASP4-004 ENSP00000376857 ENST00000393150	P49662 [Direct mapping] Caspase-4 Caspase-4 subunit 1 Caspase-4 subunit 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0042981 [regulation of apoptotic process] GO:0050727 [regulation of inflammatory response] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	321 aa 36.7 kDa	No	0
CASP4-007 ENSP00000401673 ENST00000417440	E9PMT1 [Direct mapping] Caspase-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0042981 [regulation of apoptotic process] GO:0050727 [regulation of inflammatory response] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] Show all	147 aa 17.1 kDa	No	0
CASP4-013 ENSP00000432879 ENST00000533252	H0YD34 [Direct mapping] Caspase-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0050727 [regulation of inflammatory response] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] Show all	72 aa 8.1 kDa	No	0
CASP4-201 ENSP00000482808 ENST00000613196	A0A087WZP8 [Direct mapping] Caspase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0050727 [regulation of inflammatory response] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] Show all	330 aa 37.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.