Expression of CASP4 in cancer - Summary

GENERAL INFORMATION
Gene name	CASP4
Gene description	Caspase 4, apoptosis-related cysteine peptidase
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Most tissues show cytoplasmic expression while gastro and lymphatic organs show high membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA027588 , CAB037167
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA027588	CAB037167

GENE INFORMATION
Gene name	CASP4 (HGNC Symbol)
Synonyms	ICE(rel)II, ICH-2, TX
Description	Caspase 4, apoptosis-related cysteine peptidase (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q22.3
Chromosome location (bp)	104942866 - 104969436
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000196954 (version 83.38)
Entrez gene	837
UniProt	P49662 (UniProt - Evidence at protein level)
neXtProt	NX_P49662
Antibodypedia	CASP4 antibodies

PROTEIN BROWSER

CASP4-001	CASP4-004	CASP4-007	CASP4-013	CASP4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CASP4-001 ENSP00000388566 ENST00000444739	P49662 [Direct mapping] Caspase-4 Caspase-4 subunit 1 Caspase-4 subunit 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0042981 [regulation of apoptotic process] GO:0050727 [regulation of inflammatory response] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	377 aa 43.3 kDa	No	0
CASP4-004 ENSP00000376857 ENST00000393150	P49662 [Direct mapping] Caspase-4 Caspase-4 subunit 1 Caspase-4 subunit 2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Cysteine-type peptidases Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0042981 [regulation of apoptotic process] GO:0050727 [regulation of inflammatory response] GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] GO:0097193 [intrinsic apoptotic signaling pathway] Show all	321 aa 36.7 kDa	No	0
CASP4-007 ENSP00000401673 ENST00000417440	E9PMT1 [Direct mapping] Caspase-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0042981 [regulation of apoptotic process] GO:0050727 [regulation of inflammatory response] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] Show all	147 aa 17.1 kDa	No	0
CASP4-013 ENSP00000432879 ENST00000533252	H0YD34 [Direct mapping] Caspase-4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0050727 [regulation of inflammatory response] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] Show all	72 aa 8.1 kDa	No	0
CASP4-201 ENSP00000482808 ENST00000613196	A0A087WZP8 [Direct mapping] Caspase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004197 [cysteine-type endopeptidase activity] GO:0005737 [cytoplasm] GO:0006508 [proteolysis] GO:0006915 [apoptotic process] GO:0008234 [cysteine-type peptidase activity] GO:0050727 [regulation of inflammatory response] GO:0072557 [IPAF inflammasome complex] GO:0072559 [NLRP3 inflammasome complex] GO:0097169 [AIM2 inflammasome complex] Show all	330 aa 37.9 kDa	No	0