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CASP4

GENERAL INFORMATION

Gene name

 CASP4

Gene description

 Caspase 4, apoptosis-related cysteine peptidase

Protein class

 Cancer-related genes
Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Most tissues show cytoplasmic expression while gastro and lymphatic organs show high membranous expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA027588 , CAB037167
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CASP4 (HGNC Symbol)

Synonyms

 ICE(rel)II, ICH-2, TX

Description

 Caspase 4, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q22.3

Chromosome location (bp)

 104942866 - 104969436

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000196954 (version 83.38)

Entrez gene

 837

UniProt

 P49662 (UniProt - Evidence at protein level)

neXtProt

 NX_P49662

Antibodypedia

 CASP4 antibodies

PROTEIN BROWSER
CASP4-001
CASP4-004
CASP4-007
CASP4-013
CASP4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASP4-001
ENSP00000388566
ENST00000444739
P49662 [Direct mapping]
Caspase-4 Caspase-4 subunit 1 Caspase-4 subunit 2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0042981 [regulation of apoptotic process]
GO:0050727 [regulation of inflammatory response]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0072557 [IPAF inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 377 aa
43.3 kDa 		No 0
CASP4-004
ENSP00000376857
ENST00000393150
P49662 [Direct mapping]
Caspase-4 Caspase-4 subunit 1 Caspase-4 subunit 2
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0042981 [regulation of apoptotic process]
GO:0050727 [regulation of inflammatory response]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0072557 [IPAF inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
GO:0097193 [intrinsic apoptotic signaling pathway]
Show all
 321 aa
36.7 kDa 		No 0
CASP4-007
ENSP00000401673
ENST00000417440
E9PMT1 [Direct mapping]
Caspase-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0042981 [regulation of apoptotic process]
GO:0050727 [regulation of inflammatory response]
GO:0072557 [IPAF inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 147 aa
17.1 kDa 		No 0
CASP4-013
ENSP00000432879
ENST00000533252
H0YD34 [Direct mapping]
Caspase-4
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0050727 [regulation of inflammatory response]
GO:0072557 [IPAF inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 72 aa
8.1 kDa 		No 0
CASP4-201
ENSP00000482808
ENST00000613196
A0A087WZP8 [Direct mapping]
Caspase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0050727 [regulation of inflammatory response]
GO:0072557 [IPAF inflammasome complex]
GO:0072559 [NLRP3 inflammasome complex]
GO:0097169 [AIM2 inflammasome complex]
Show all
 330 aa
37.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.