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DMBX1

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GENERAL INFORMATION

Gene name

 DMBX1

Gene description

 Diencephalon/mesencephalon homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (AN3-CA, SiHa, K-562)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AN3-CA, SiHa, K-562)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DMBX1 (HGNC Symbol)

Synonyms

 OTX3, PAXB

Description

 Diencephalon/mesencephalon homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p33

Chromosome location (bp)

 46506996 - 46514226

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000197587 (version 83.38)

Entrez gene

 127343

UniProt

 Q8NFW5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFW5

Antibodypedia

 DMBX1 antibodies

PROTEIN BROWSER
DMBX1-001
DMBX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DMBX1-001
ENSP00000353132
ENST00000360032
Q8NFW5 [Direct mapping]
Diencephalon/mesencephalon homeobox protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0008343 [adult feeding behavior]
GO:0008344 [adult locomotory behavior]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0048589 [developmental growth]
Show all
 377 aa
40.7 kDa 		No 0
DMBX1-201
ENSP00000361024
ENST00000371956
Q8NFW5 [Direct mapping]
Diencephalon/mesencephalon homeobox protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048589 [developmental growth]
Show all
 382 aa
41.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.