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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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DMBX1
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

DMBX1

Gene description

Diencephalon/mesencephalon homeobox 1

Protein class

Predicted intracellular proteins
Transcription factors

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (AN3-CA, K-562, SiHa)
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA026811
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA026811

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Most cancer displayed moderate positivity. Cases of hepatocellular carcinomas, melanoma and thyroid cancer showed strong immunoreactivity.

GENE INFORMATION

Gene name

DMBX1 (HGNC Symbol)

Synonyms

OTX3, PAXB

Description

Diencephalon/mesencephalon homeobox 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

1

Cytoband

p33

Chromosome location (bp)

46506996 - 46514226

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197587 (version 83.38)

Entrez gene

127343

UniProt

Q8NFW5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NFW5

Antibodypedia

DMBX1 antibodies

PROTEIN BROWSER

DMBX1-001
DMBX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DMBX1-001
ENSP00000353132
ENST00000360032
Q8NFW5 [Direct mapping]
Diencephalon/mesencephalon homeobox protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0008343 [adult feeding behavior]
GO:0008344 [adult locomotory behavior]
GO:0042803 [protein homodimerization activity]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0048589 [developmental growth]
Show all
377 aa
40.7 kDa
No 0
DMBX1-201
ENSP00000361024
ENST00000371956
Q8NFW5 [Direct mapping]
Diencephalon/mesencephalon homeobox protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007417 [central nervous system development]
GO:0007420 [brain development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0048589 [developmental growth]
Show all
382 aa
41.2 kDa
No 0

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