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ENPP1
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ENPP1

Gene description

Ectonucleotide pyrophosphatase/phosphodiesterase 1

Protein class

CD markers
Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (parathyroid gland, placenta)
GTEx:Tissue enhanced (endometrium)
FANTOM5:Mixed

Protein evidence

Evidence at protein level

Protein expression

Membranous expression in a subset of cells including placental stroma, chondrocytes, exocrine pancreas, renal tubules, thyroid and parathyroid gland.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 2 antibodies.
HPA062066 , CAB032904
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
N/A
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (parathyroid gland, placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (endometrium)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

ENPP1 (HGNC Symbol)

Synonyms

M6S1, NPPS, PC-1, PCA1, PDNP1

Description

Ectonucleotide pyrophosphatase/phosphodiesterase 1 (HGNC Symbol)

Entrez gene summary

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

q23.2

Chromosome location (bp)

131808016 - 131895155

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000197594 (version 83.38)

Entrez gene

5167

UniProt

P22413 (UniProt - Evidence at protein level)

neXtProt

NX_P22413

Antibodypedia

ENPP1 antibodies

PROTEIN BROWSER

ENPP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ENPP1-001
ENSP00000354238
ENST00000360971
P22413 [Direct mapping]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Alkaline phosphodiesterase I Nucleotide pyrophosphatase
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Enzymes
   ENZYME proteins
   Hydrolases
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0003824 [catalytic activity]
GO:0004528 [phosphodiesterase I activity]
GO:0004551 [nucleotide diphosphatase activity]
GO:0005044 [scavenger receptor activity]
GO:0005158 [insulin receptor binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006091 [generation of precursor metabolites and energy]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006771 [riboflavin metabolic process]
GO:0006796 [phosphate-containing compound metabolic process]
GO:0006898 [receptor-mediated endocytosis]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0008270 [zinc ion binding]
GO:0009143 [nucleoside triphosphate catabolic process]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016787 [hydrolase activity]
GO:0030247 [polysaccharide binding]
GO:0030308 [negative regulation of cell growth]
GO:0030500 [regulation of bone mineralization]
GO:0030505 [inorganic diphosphate transport]
GO:0030643 [cellular phosphate ion homeostasis]
GO:0030730 [sequestering of triglyceride]
GO:0031214 [biomineral tissue development]
GO:0031953 [negative regulation of protein autophosphorylation]
GO:0032869 [cellular response to insulin stimulus]
GO:0035529 [NADH pyrophosphatase activity]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045719 [negative regulation of glycogen biosynthetic process]
GO:0046325 [negative regulation of glucose import]
GO:0046627 [negative regulation of insulin receptor signaling pathway]
GO:0046872 [metal ion binding]
GO:0047429 [nucleoside-triphosphate diphosphatase activity]
GO:0050427 [3'-phosphoadenosine 5'-phosphosulfate metabolic process]
GO:0050656 [3'-phosphoadenosine 5'-phosphosulfate binding]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
Show all
925 aa
104.9 kDa
No 1

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