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TLK1

GENERAL INFORMATION

Gene name

 TLK1

Gene description

 Tousled-like kinase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA016043
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016043

GENE INFORMATION

Gene name

 TLK1 (HGNC Symbol)

Synonyms

 KIAA0137, PKU-BETA

Description

 Tousled-like kinase 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 170990823 - 171231314

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000198586 (version 83.38)

Entrez gene

 9874

UniProt

 Q9UKI8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKI8

Antibodypedia

 TLK1 antibodies

PROTEIN BROWSER
TLK1-001
TLK1-002
TLK1-005
TLK1-010
TLK1-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TLK1-001
ENSP00000411099
ENST00000431350
Q9UKI8 [Direct mapping]
Serine/threonine-protein kinase tousled-like 1
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001672 [regulation of chromatin assembly or disassembly]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006886 [intracellular protein transport]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0016568 [chromatin modification]
GO:0035556 [intracellular signal transduction]
Show all
 766 aa
86.7 kDa 		No 0
TLK1-002
ENSP00000354089
ENST00000360843
Q9UKI8 [Direct mapping]
Serine/threonine-protein kinase tousled-like 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001672 [regulation of chromatin assembly or disassembly]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006886 [intracellular protein transport]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0016568 [chromatin modification]
GO:0035556 [intracellular signal transduction]
Show all
 787 aa
89 kDa 		No 0
TLK1-005
ENSP00000409222
ENST00000434911
Q9UKI8 [Direct mapping]
Serine/threonine-protein kinase tousled-like 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001672 [regulation of chromatin assembly or disassembly]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006886 [intracellular protein transport]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0016568 [chromatin modification]
GO:0035556 [intracellular signal transduction]
Show all
 670 aa
77.1 kDa 		No 0
TLK1-010
ENSP00000393165
ENST00000453628
C9JWT6 [Direct mapping]
Serine/threonine-protein kinase tousled-like 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 162 aa
17.7 kDa 		No 0
TLK1-012
ENSP00000428113
ENST00000521943
Q9UKI8 [Direct mapping]
Serine/threonine-protein kinase tousled-like 1
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001672 [regulation of chromatin assembly or disassembly]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0006886 [intracellular protein transport]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007049 [cell cycle]
GO:0016568 [chromatin modification]
GO:0035556 [intracellular signal transduction]
Show all
 718 aa
81.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.