Tissue expression of TLK1 - Summary - The Human Protein Atlas

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TLK1

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TLK1
Gene description	Tousled-like kinase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

General nuclear and cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA016043
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

N/A

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	TLK1 (HGNC Symbol)
Synonyms	KIAA0137, PKU-BETA
Description	Tousled-like kinase 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	170990823 - 171231314
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000198586 (version 83.38)
Entrez gene	9874
UniProt	Q9UKI8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UKI8
Antibodypedia	TLK1 antibodies

PROTEIN BROWSER

TLK1-001	TLK1-002	TLK1-005	TLK1-010	TLK1-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TLK1-001 ENSP00000411099 ENST00000431350	Q9UKI8 [Direct mapping] Serine/threonine-protein kinase tousled-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001672 [regulation of chromatin assembly or disassembly] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0006886 [intracellular protein transport] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0016568 [chromatin modification] GO:0035556 [intracellular signal transduction] Show all	766 aa 86.7 kDa	No	0
TLK1-002 ENSP00000354089 ENST00000360843	Q9UKI8 [Direct mapping] Serine/threonine-protein kinase tousled-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001672 [regulation of chromatin assembly or disassembly] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0006886 [intracellular protein transport] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0016568 [chromatin modification] GO:0035556 [intracellular signal transduction] Show all	787 aa 89 kDa	No	0
TLK1-005 ENSP00000409222 ENST00000434911	Q9UKI8 [Direct mapping] Serine/threonine-protein kinase tousled-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001672 [regulation of chromatin assembly or disassembly] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0006886 [intracellular protein transport] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0016568 [chromatin modification] GO:0035556 [intracellular signal transduction] Show all	670 aa 77.1 kDa	No	0
TLK1-010 ENSP00000393165 ENST00000453628	C9JWT6 [Direct mapping] Serine/threonine-protein kinase tousled-like 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	162 aa 17.7 kDa	No	0
TLK1-012 ENSP00000428113 ENST00000521943	Q9UKI8 [Direct mapping] Serine/threonine-protein kinase tousled-like 1 Show all	Enzymes ENZYME proteins Transferases Kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001672 [regulation of chromatin assembly or disassembly] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0006468 [protein phosphorylation] GO:0006886 [intracellular protein transport] GO:0006974 [cellular response to DNA damage stimulus] GO:0007049 [cell cycle] GO:0016568 [chromatin modification] GO:0035556 [intracellular signal transduction] Show all	718 aa 81.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.