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CD3E
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    TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CD3E

Gene description

CD3e molecule, epsilon (CD3-TCR complex)

Protein class

CD markers
Disease related genes
FDA approved drug targets
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (lymph node, tonsil)
GTEx:Group enriched (lung, small intestine, spleen)
FANTOM5:Tissue enhanced (lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in T-cells.

DATA RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 5 antibodies.
HPA040957 , HPA043955 , CAB000010 , CAB072863 , CAB072864
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Tonsil

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (lung, small intestine, spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lymph node, tonsil)

GENE INFORMATION

Gene name

CD3E

Synonyms

Description

CD3e molecule, epsilon (CD3-TCR complex) (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q23.3

Chromosome location (bp)

118304545 - 118316175

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198851 (version 83.38)

Entrez gene

916

UniProt

P07766 (UniProt - Evidence at protein level)

neXtProt

NX_P07766

Antibodypedia

CD3E antibodies

PROTEIN BROWSER

CD3E-001
CD3E-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD3E-001
ENSP00000354566
ENST00000361763
P07766 [Direct mapping]
T-cell surface glycoprotein CD3 epsilon chain
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001772 [immunological synapse]
GO:0002669 [positive regulation of T cell anergy]
GO:0004871 [signal transducer activity]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0006461 [protein complex assembly]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007584 [response to nutrient]
GO:0009897 [external side of plasma membrane]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0016020 [membrane]
GO:0017124 [SH3 domain binding]
GO:0019901 [protein kinase binding]
GO:0030159 [receptor signaling complex scaffold activity]
GO:0031295 [T cell costimulation]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0033077 [T cell differentiation in thymus]
GO:0035556 [intracellular signal transduction]
GO:0042101 [T cell receptor complex]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042105 [alpha-beta T cell receptor complex]
GO:0042110 [T cell activation]
GO:0042608 [T cell receptor binding]
GO:0042981 [regulation of apoptotic process]
GO:0045060 [negative thymic T cell selection]
GO:0045086 [positive regulation of interleukin-2 biosynthetic process]
GO:0045879 [negative regulation of smoothened signaling pathway]
GO:0046641 [positive regulation of alpha-beta T cell proliferation]
GO:0046649 [lymphocyte activation]
GO:0046982 [protein heterodimerization activity]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050776 [regulation of immune response]
GO:0050850 [positive regulation of calcium-mediated signaling]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0097190 [apoptotic signaling pathway]
Show all
207 aa
23.1 kDa
Yes 1
CD3E-007
ENSP00000433975
ENST00000528600
E9PSH8 [Direct mapping]
T-cell surface glycoprotein CD3 epsilon chain
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004888 [transmembrane signaling receptor activity]
GO:0005515 [protein binding]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
201 aa
22.6 kDa
Yes 1

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