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NELFE

GENERAL INFORMATION

Gene name

 NELFE

Gene description

 Negative elongation factor complex member E

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA007187
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007187

GENE INFORMATION

Gene name

 NELFE (HGNC Symbol)

Synonyms

 D6S45, NELF-E, RD, RDBP, RDP

Description

 Negative elongation factor complex member E (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p21.33

Chromosome location (bp)

 31952087 - 31959110

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204356 (version 83.38)

Entrez gene

 7936

UniProt

 P18615 (UniProt - Evidence at protein level)

neXtProt

 NX_P18615

Antibodypedia

 NELFE antibodies

PROTEIN BROWSER
NELFE-001
NELFE-007
NELFE-009
NELFE-010
NELFE-011
NELFE-012
NELFE-013
NELFE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NELFE-001
ENSP00000364578
ENST00000375429
P18615 [Direct mapping]
Negative elongation factor E
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003682 [chromatin binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032021 [NELF complex]
GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter]
GO:0044822 [poly(A) RNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0051571 [positive regulation of histone H3-K4 methylation]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:1900364 [negative regulation of mRNA polyadenylation]
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 380 aa
43.2 kDa 		No 0
NELFE-007
ENSP00000397914
ENST00000441998
A0A0A0MSN9 [Direct mapping]
Negative elongation factor E
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
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 334 aa
38.2 kDa 		No 0
NELFE-009
ENSP00000394340
ENST00000426722
A2ABK4 [Direct mapping]
Negative elongation factor E
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
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 159 aa
17.3 kDa 		No 0
NELFE-010
ENSP00000414029
ENST00000436289
E9PD43 [Direct mapping]
Negative elongation factor E
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
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 260 aa
30.1 kDa 		No 0
NELFE-011
ENSP00000409389
ENST00000454913
A0A0A0MT02 [Direct mapping]
Negative elongation factor E
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 294 aa
33.7 kDa 		No 0
NELFE-012
ENSP00000388400
ENST00000444811
P18615 [Direct mapping]
Negative elongation factor E
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032021 [NELF complex]
GO:0044822 [poly(A) RNA binding]
GO:0050434 [positive regulation of viral transcription]
GO:1900364 [negative regulation of mRNA polyadenylation]
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 350 aa
40.2 kDa 		No 0
NELFE-013
ENSP00000364574
ENST00000375425
P18615 [Direct mapping]
Negative elongation factor E
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0003676 [nucleic acid binding]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0008150 [biological_process]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0032021 [NELF complex]
GO:0044822 [poly(A) RNA binding]
GO:0050434 [positive regulation of viral transcription]
GO:1900364 [negative regulation of mRNA polyadenylation]
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 387 aa
43.9 kDa 		No 0
NELFE-201
ENSP00000486884
ENST00000625905
E7ENC7 [Direct mapping]
Negative elongation factor E
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 36 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.