Tissue expression of NELFE - Summary - The Human Protein Atlas

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NELFE

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NELFE
Gene description	Negative elongation factor complex member E
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Mainly nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007187
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NELFE (HGNC Symbol)
Synonyms	D6S45, NELF-E, RD, RDBP, RDP
Description	Negative elongation factor complex member E (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31952087 - 31959110
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204356 (version 83.38)
Entrez gene	7936
UniProt	P18615 (UniProt - Evidence at protein level)
neXtProt	NX_P18615
Antibodypedia	NELFE antibodies

PROTEIN BROWSER

NELFE-001	NELFE-007	NELFE-009	NELFE-010	NELFE-011	NELFE-012	NELFE-013	NELFE-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NELFE-001 ENSP00000364578 ENST00000375429	P18615 [Direct mapping] Negative elongation factor E Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003682 [chromatin binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0008150 [biological_process] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0032021 [NELF complex] GO:0034244 [negative regulation of transcription elongation from RNA polymerase II promoter] GO:0044822 [poly(A) RNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050434 [positive regulation of viral transcription] GO:0051571 [positive regulation of histone H3-K4 methylation] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	380 aa 43.2 kDa	No	0
NELFE-007 ENSP00000397914 ENST00000441998	A0A0A0MSN9 [Direct mapping] Negative elongation factor E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	334 aa 38.2 kDa	No	0
NELFE-009 ENSP00000394340 ENST00000426722	A2ABK4 [Direct mapping] Negative elongation factor E Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] Show all	159 aa 17.3 kDa	No	0
NELFE-010 ENSP00000414029 ENST00000436289	E9PD43 [Direct mapping] Negative elongation factor E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] Show all	260 aa 30.1 kDa	No	0
NELFE-011 ENSP00000409389 ENST00000454913	A0A0A0MT02 [Direct mapping] Negative elongation factor E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		294 aa 33.7 kDa	No	0
NELFE-012 ENSP00000388400 ENST00000444811	P18615 [Direct mapping] Negative elongation factor E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0008150 [biological_process] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0032021 [NELF complex] GO:0044822 [poly(A) RNA binding] GO:0050434 [positive regulation of viral transcription] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	350 aa 40.2 kDa	No	0
NELFE-013 ENSP00000364574 ENST00000375425	P18615 [Direct mapping] Negative elongation factor E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005739 [mitochondrion] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0008150 [biological_process] GO:0010467 [gene expression] GO:0016032 [viral process] GO:0032021 [NELF complex] GO:0044822 [poly(A) RNA binding] GO:0050434 [positive regulation of viral transcription] GO:1900364 [negative regulation of mRNA polyadenylation] Show all	387 aa 43.9 kDa	No	0
NELFE-201 ENSP00000486884 ENST00000625905	E7ENC7 [Direct mapping] Negative elongation factor E Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		36 aa 4.1 kDa	No	0

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