Expression of PRRC2A in cancer - Summary - The Human Protein Atlas

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PRRC2A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRRC2A
Gene description	Proline-rich coiled-coil 2A
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEK93, U-266/70, U-266/84, U-698)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA046791 , CAB026383
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046791	CAB026383

GENE INFORMATION
Gene name	PRRC2A (HGNC Symbol)
Synonyms	BAT2, D6S51E, G2
Description	Proline-rich coiled-coil 2A (HGNC Symbol)
Entrez gene summary	A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31620720 - 31637771
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000204469 (version 83.38)
Entrez gene	7916
UniProt	P48634 (UniProt - Evidence at protein level)
neXtProt	NX_P48634
Antibodypedia	PRRC2A antibodies

PROTEIN BROWSER

PRRC2A-001	PRRC2A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRRC2A-001 ENSP00000365175 ENST00000376007	P48634 [Direct mapping] Protein PRRC2A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016020 [membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	2157 aa 228.9 kDa	No	0
PRRC2A-002 ENSP00000365201 ENST00000376033	P48634 [Direct mapping] Protein PRRC2A Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0016020 [membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0070062 [extracellular exosome] Show all	2157 aa 228.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.