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TRIM31

GENERAL INFORMATION

Gene name

 TRIM31

Gene description

 Tripartite motif containing 31

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (cervical cancer, colorectal cancer, pancreatic cancer, stomach cancer, urothelial cancer)
HPA (cell line):Cell line enriched (RT4)
HPA (normal tissue):Group enriched (colon, small intestine, stomach, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplsmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA046400
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (cervical cancer, colorectal cancer, pancreatic cancer, stomach cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046400

GENE INFORMATION

Gene name

 TRIM31 (HGNC Symbol)

Synonyms

 C6orf13, HCG1, HCGI, RNF

Description

 Tripartite motif containing 31 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to both the cytoplasm and the nucleus. Its function has not been identified. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.1

Chromosome location (bp)

 30102897 - 30113106

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000204616 (version 83.38)

Entrez gene

 11074

UniProt

 Q9BZY9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZY9

Antibodypedia

 TRIM31 antibodies

PROTEIN BROWSER
TRIM31-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRIM31-001
ENSP00000365924
ENST00000376734
Q9BZY9 [Direct mapping]
E3 ubiquitin-protein ligase TRIM31
Q2L6J1 [Target identity:100%; Query identity:100%]
Tripartite motif-containing 31; cDNA FLJ75322, highly similar to Homo sapiens tripartite motif-containing 31, transcript variant 1, mRNA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032897 [negative regulation of viral transcription]
GO:0045087 [innate immune response]
GO:0046597 [negative regulation of viral entry into host cell]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:1902186 [regulation of viral release from host cell]
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 425 aa
48.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.