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Gene name

Class

Subclass

Chromosome

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In atlas

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Reliability

Reliability

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Method

Validation

Method

Validation

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Cancer

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Tissue

Detectable

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CAPN14
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PATHOLOGY ATLAS

GENE/PROTEIN

Dictionary

GENERAL INFORMATION

Gene name

CAPN14

Gene description

Calpain 14

Protein class

Enzymes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Group enriched (cervical cancer, head and neck cancer, lung cancer, stomach cancer, urothelial cancer)
HPA (cell line):Cell line enhanced (U-266/70)
HPA (normal tissue):Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

Pending cancer tissue analysis.

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Group enriched (cervical cancer, head and neck cancer, lung cancer, stomach cancer, urothelial cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis


STAINING SUMMARY

 

GENE INFORMATION

Gene name

CAPN14

Synonyms

Description

Calpain 14 (HGNC Symbol)

Entrez gene summary

Calpains are a family of cytosolic calcium-activated cysteine proteases involved in a variety of cellular processes including apoptosis, cell division, modulation of integrin-cytoskeletal interactions, and synaptic plasticity (Dear et al., 2000 [PubMed 10964513]). CAPN14 belongs to the calpain large subunit family.[supplied by OMIM, Mar 2008]

Chromosome

2

Cytoband

p23.1

Chromosome location (bp)

31173056 - 31233858

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000214711 (version 83.38)

Entrez gene

440854

UniProt

A8MX76 (UniProt - Evidence at transcript level)

neXtProt

NX_A8MX76

Antibodypedia

CAPN14 antibodies

PROTEIN BROWSER

CAPN14-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAPN14-002
ENSP00000385247
ENST00000403897
A8MX76 [Direct mapping]
Calpain-14
Show all
Enzymes
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
Show all
684 aa
79.6 kDa
No 0

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