Cell atlas - GCGR - The Human Protein Atlas

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GCGR

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	GCGR
Gene description	Glucagon receptor
Protein class	FDA approved drug targets G-protein coupled receptors Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (U-87 MG, MCF7, SK-BR-3, HeLa)
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA071228
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-87 MG, MCF7, SK-BR-3, HeLa) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071228	HeLa	Nucleus
	HPA071228	HeLa	Golgi apparatus
	HPA071228	SH-SY5Y	Nucleus
	HPA071228	SH-SY5Y	Golgi apparatus
	HPA071228	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	GCGR (HGNC Symbol)
Synonyms	GGR
Description	Glucagon receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81804132 - 81814013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000215644 (version 83.38)
Entrez gene	2642
UniProt	P47871 (UniProt - Evidence at protein level)
neXtProt	NX_P47871
Antibodypedia	GCGR antibodies

PROTEIN BROWSER

GCGR-001	GCGR-002	GCGR-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCGR-001 ENSP00000383558 ENST00000400723	P47871 [Direct mapping] Glucagon receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006112 [energy reserve metabolic process] GO:0006887 [exocytosis] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008217 [regulation of blood pressure] GO:0009755 [hormone-mediated signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0042593 [glucose homeostasis] GO:0042594 [response to starvation] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0070873 [regulation of glycogen metabolic process] GO:0071377 [cellular response to glucagon stimulus] Show all	477 aa 54 kDa	Yes	7
GCGR-002 ENSP00000460976 ENST00000570996	I3L454 [Direct mapping] Glucagon receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071377 [cellular response to glucagon stimulus] Show all	523 aa 57.8 kDa	Yes	6
GCGR-004 ENSP00000458930 ENST00000573428	I3L1L8 [Direct mapping] Glucagon receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0071377 [cellular response to glucagon stimulus] Show all	80 aa 9.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.