Tissue expression of GCGR - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GCGR
Gene description	Glucagon receptor
Protein class	FDA approved drug targets G-protein coupled receptors Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (adrenal gland, kidney, liver, parathyroid gland)
GTEx:	Group enriched (kidney, liver)
FANTOM5:	Tissue enriched (liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (adrenal gland, kidney, liver, parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (kidney, liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (liver)

GENE INFORMATION
Gene name	GCGR (HGNC Symbol)
Synonyms	GGR
Description	Glucagon receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81804132 - 81814013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000215644 (version 83.38)
Entrez gene	2642
UniProt	P47871 (UniProt - Evidence at protein level)
neXtProt	NX_P47871
Antibodypedia	GCGR antibodies

PROTEIN BROWSER

GCGR-001	GCGR-002	GCGR-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCGR-001 ENSP00000383558 ENST00000400723	P47871 [Direct mapping] Glucagon receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006112 [energy reserve metabolic process] GO:0006887 [exocytosis] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008217 [regulation of blood pressure] GO:0009755 [hormone-mediated signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0042593 [glucose homeostasis] GO:0042594 [response to starvation] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0070873 [regulation of glycogen metabolic process] GO:0071377 [cellular response to glucagon stimulus] Show all	477 aa 54 kDa	Yes	7
GCGR-002 ENSP00000460976 ENST00000570996	I3L454 [Direct mapping] Glucagon receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071377 [cellular response to glucagon stimulus] Show all	523 aa 57.8 kDa	Yes	6
GCGR-004 ENSP00000458930 ENST00000573428	I3L1L8 [Direct mapping] Glucagon receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0071377 [cellular response to glucagon stimulus] Show all	80 aa 9.1 kDa	Yes	0