Expression of GCGR in cancer - Summary - The Human Protein Atlas

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GCGR

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	GCGR
Gene description	Glucagon receptor
Protein class	FDA approved drug targets G-protein coupled receptors Plasma proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (liver cancer)
HPA (cell line):	Cell line enhanced (HeLa, MCF7, SK-BR-3, U-87 MG)
HPA (normal tissue):	Group enriched (adrenal gland, kidney, liver, parathyroid gland)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	GCGR (HGNC Symbol)
Synonyms	GGR
Description	Glucagon receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	81804132 - 81814013
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000215644 (version 83.38)
Entrez gene	2642
UniProt	P47871 (UniProt - Evidence at protein level)
neXtProt	NX_P47871
Antibodypedia	GCGR antibodies

PROTEIN BROWSER

GCGR-001	GCGR-002	GCGR-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCGR-001 ENSP00000383558 ENST00000400723	P47871 [Direct mapping] Glucagon receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006091 [generation of precursor metabolites and energy] GO:0006112 [energy reserve metabolic process] GO:0006887 [exocytosis] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007584 [response to nutrient] GO:0008217 [regulation of blood pressure] GO:0009755 [hormone-mediated signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0017046 [peptide hormone binding] GO:0042593 [glucose homeostasis] GO:0042594 [response to starvation] GO:0043547 [positive regulation of GTPase activity] GO:0044281 [small molecule metabolic process] GO:0070873 [regulation of glycogen metabolic process] GO:0071377 [cellular response to glucagon stimulus] Show all	477 aa 54 kDa	Yes	7
GCGR-002 ENSP00000460976 ENST00000570996	I3L454 [Direct mapping] Glucagon receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0071377 [cellular response to glucagon stimulus] Show all	523 aa 57.8 kDa	Yes	6
GCGR-004 ENSP00000458930 ENST00000573428	I3L1L8 [Direct mapping] Glucagon receptor Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004967 [glucagon receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0071377 [cellular response to glucagon stimulus] Show all	80 aa 9.1 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.