Expression of SMIM1 in cancer - Summary

GENERAL INFORMATION
Gene name	SMIM1
Gene description	Small integral membrane protein 1 (Vel blood group)
Protein class	Blood group antigen proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (HEL, Hep G2, K-562)
HPA (normal tissue):	Tissue enhanced (bone marrow, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, with additional membranous expression in few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA069088
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA069088

GENE INFORMATION
Gene name	SMIM1 (HGNC Symbol)
Synonyms	Vel
Description	Small integral membrane protein 1 (Vel blood group) (HGNC Symbol)
Entrez gene summary	This gene encodes a small, conserved protein that participates in red blood cell formation. The encoded protein is localized to the cell membrane and is the antigen for the Vel blood group. Alternative splicing results in different transcript variants that encode the same protein. [provided by RefSeq, Dec 2013]
Chromosome	1
Cytoband	p36.32
Chromosome location (bp)	3772788 - 3775982
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000235169 (version 83.38)
Entrez gene	388588
UniProt	B2RUZ4 (UniProt - Evidence at protein level)
neXtProt	NX_B2RUZ4
Antibodypedia	SMIM1 antibodies

PROTEIN BROWSER

SMIM1-001	SMIM1-002	SMIM1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMIM1-001 ENSP00000457386 ENST00000444870	B2RUZ4 [Direct mapping] Small integral membrane protein 1 M4WDD3 [Target identity:100%; Query identity:100%] Small integral membrane protein 1 Show all	Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0070062 [extracellular exosome] Show all	78 aa 8.7 kDa	No	1
SMIM1-002 ENSP00000457674 ENST00000452264		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		5 aa 0.6 kDa	No	0
SMIM1-003 ENSP00000456559 ENST00000561886	H3BS66 [Direct mapping] Small integral membrane protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.2 kDa	No	0