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SMIM1

GENERAL INFORMATION

Gene name

 SMIM1

Gene description

 Small integral membrane protein 1 (Vel blood group)

Protein class

 Blood group antigen proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow, testis)
GTEx:Tissue enhanced (testis)
FANTOM5:Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, with additional membranous expression in few tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA069088
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Seminal vesicle

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (testis)

GENE INFORMATION

Gene name

 SMIM1 (HGNC Symbol)

Synonyms

 Vel

Description

 Small integral membrane protein 1 (Vel blood group) (HGNC Symbol)

Entrez gene summary

 This gene encodes a small, conserved protein that participates in red blood cell formation. The encoded protein is localized to the cell membrane and is the antigen for the Vel blood group. Alternative splicing results in different transcript variants that encode the same protein. [provided by RefSeq, Dec 2013]

Chromosome

 1

Cytoband

 p36.32

Chromosome location (bp)

 3772788 - 3775982

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000235169 (version 83.38)

Entrez gene

 388588

UniProt

 B2RUZ4 (UniProt - Evidence at protein level)

neXtProt

 NX_B2RUZ4

Antibodypedia

 SMIM1 antibodies

PROTEIN BROWSER
SMIM1-001
SMIM1-002
SMIM1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMIM1-001
ENSP00000457386
ENST00000444870
B2RUZ4 [Direct mapping]
Small integral membrane protein 1
M4WDD3 [Target identity:100%; Query identity:100%]
Small integral membrane protein 1
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Blood group antigen proteins
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0016021 [integral component of membrane]
GO:0070062 [extracellular exosome]
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 78 aa
8.7 kDa 		No 1
SMIM1-002
ENSP00000457674
ENST00000452264
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 5 aa
0.6 kDa 		No 0
SMIM1-003
ENSP00000456559
ENST00000561886
H3BS66 [Direct mapping]
Small integral membrane protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 37 aa
4.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.