Cell atlas - CFB - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CFB

premium

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions
	Vesicles

Human cell
	Plasma Membrane
	Vesicles

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CFB
Gene description	Complement factor B
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (CAPAN-2, EFO-21, ASC TERT1)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (uncertain), Cell Junctions (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA000951
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (CAPAN-2, EFO-21, ASC TERT1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions & vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (uncertain), Cell Junctions (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA000951	A-431	Cell Junctions
	HPA000951	ASC TERT1	Vesicles

GENE INFORMATION
Gene name	CFB (HGNC Symbol)
Synonyms	BF, BFD, H2-Bf
Description	Complement factor B (HGNC Symbol)
Entrez gene summary	This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31945650 - 31952084
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243649 (version 83.38)
Entrez gene	629
UniProt	P00751 (UniProt - Evidence at protein level)
neXtProt	NX_P00751
Antibodypedia	CFB antibodies

PROTEIN BROWSER

CFB-001	CFB-002	CFB-012	CFB-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFB-001 ENSP00000416561 ENST00000425368	P00751 [Direct mapping] Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001848 [complement binding] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006957 [complement activation, alternative pathway] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	764 aa 85.5 kDa	Yes	0
CFB-002 ENSP00000420090 ENST00000475617	C9JRT3 [Direct mapping] Complement factor B Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		144 aa 16.1 kDa	Yes	0
CFB-012 ENSP00000418833 ENST00000498317	H7C526 [Direct mapping] Complement factor B Show all	Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	68 aa 7.3 kDa	No	0
CFB-013 ENSP00000419887 ENST00000483004	H7C5H1 [Direct mapping] Complement factor B Show all	Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	305 aa 34.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.