Expression of CFB in cancer - Summary - The Human Protein Atlas

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CFB

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CFB
Gene description	Complement factor B
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, CAPAN-2, EFO-21)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma. Cytoplasmic expression a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 3 antibodies. HPA001817 , HPA001832 , CAB016381
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001817	HPA001832	CAB016381

GENE INFORMATION
Gene name	CFB (HGNC Symbol)
Synonyms	BF, BFD, H2-Bf
Description	Complement factor B (HGNC Symbol)
Entrez gene summary	This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	p21.33
Chromosome location (bp)	31945650 - 31952084
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000243649 (version 83.38)
Entrez gene	629
UniProt	P00751 (UniProt - Evidence at protein level)
neXtProt	NX_P00751
Antibodypedia	CFB antibodies

PROTEIN BROWSER

CFB-001	CFB-002	CFB-012	CFB-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFB-001 ENSP00000416561 ENST00000425368	P00751 [Direct mapping] Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001848 [complement binding] GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006508 [proteolysis] GO:0006956 [complement activation] GO:0006957 [complement activation, alternative pathway] GO:0030449 [regulation of complement activation] GO:0045087 [innate immune response] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	764 aa 85.5 kDa	Yes	0
CFB-002 ENSP00000420090 ENST00000475617	C9JRT3 [Direct mapping] Complement factor B Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		144 aa 16.1 kDa	Yes	0
CFB-012 ENSP00000418833 ENST00000498317	H7C526 [Direct mapping] Complement factor B Show all	Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	68 aa 7.3 kDa	No	0
CFB-013 ENSP00000419887 ENST00000483004	H7C5H1 [Direct mapping] Complement factor B Show all	Predicted intracellular proteins Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	305 aa 34.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.