Cell atlas - CFHR1 - The Human Protein Atlas

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CFHR1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	CFHR1
Gene description	Complement factor H-related 1
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category	Cell line enhanced (U-266/70, HL-60)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA038922
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-266/70, HL-60) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA038922	A-431	Vesicles
	HPA038922	U-2 OS	No staining
	HPA038922	U-251 MG	Vesicles

GENE INFORMATION
Gene name	CFHR1 (HGNC Symbol)
Synonyms	CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2
Description	Complement factor H-related 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	196819757 - 196832189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244414 (version 83.38)
Entrez gene	3078
UniProt	Q03591 (UniProt - Evidence at protein level)
neXtProt	NX_Q03591
Antibodypedia	CFHR1 antibodies

PROTEIN BROWSER

CFHR1-001	CFHR1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFHR1-001 ENSP00000314299 ENST00000320493	Q03591 [Direct mapping] Complement factor H-related protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006956 [complement activation] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	330 aa 37.7 kDa	Yes	0
CFHR1-002 ENSP00000356394 ENST00000367424	B1AKG0 [Direct mapping] Complement factor H-related protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		271 aa 30.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.