Expression of CFHR1 in cancer - Summary - The Human Protein Atlas

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CFHR1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CFHR1
Gene description	Complement factor H-related 1
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (HL-60, U-266/70)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct positivity in plasma, extracellular matrix and proximal renal tubules.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, targets protein from more than one gene. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 3 antibodies. HPA038915 , HPA038922 , HPA040726
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038915	HPA038922	HPA040726

GENE INFORMATION
Gene name	CFHR1 (HGNC Symbol)
Synonyms	CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2
Description	Complement factor H-related 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
Chromosome	1
Cytoband	q31.3
Chromosome location (bp)	196819757 - 196832189
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000244414 (version 83.38)
Entrez gene	3078
UniProt	Q03591 (UniProt - Evidence at protein level)
neXtProt	NX_Q03591
Antibodypedia	CFHR1 antibodies

PROTEIN BROWSER

CFHR1-001	CFHR1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CFHR1-001 ENSP00000314299 ENST00000320493	Q03591 [Direct mapping] Complement factor H-related protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005615 [extracellular space] GO:0006956 [complement activation] GO:0070062 [extracellular exosome] GO:0072562 [blood microparticle] Show all	330 aa 37.7 kDa	Yes	0
CFHR1-002 ENSP00000356394 ENST00000367424	B1AKG0 [Direct mapping] Complement factor H-related protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		271 aa 30.9 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.