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LYN proto-oncogene, Src family tyrosine kinase (HGNC Symbol)
Entrez gene summary
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001782 [B cell homeostasis] GO:0001817 [regulation of cytokine production] GO:0001932 [regulation of protein phosphorylation] GO:0001933 [negative regulation of protein phosphorylation] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002431 [Fc receptor mediated stimulatory signaling pathway] GO:0002513 [tolerance induction to self antigen] GO:0002553 [histamine secretion by mast cell] GO:0002576 [platelet degranulation] GO:0002762 [negative regulation of myeloid leukocyte differentiation] GO:0002768 [immune response-regulating cell surface receptor signaling pathway] GO:0002774 [Fc receptor mediated inhibitory signaling pathway] GO:0002902 [regulation of B cell apoptotic process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005758 [mitochondrial intermembrane space] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006991 [response to sterol depletion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0009725 [response to hormone] GO:0009743 [response to carbohydrate] GO:0010976 [positive regulation of neuron projection development] GO:0014003 [oligodendrocyte development] GO:0014069 [postsynaptic density] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016032 [viral process] GO:0017124 [SH3 domain binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0030061 [mitochondrial crista] GO:0030097 [hemopoiesis] GO:0030168 [platelet activation] GO:0030218 [erythrocyte differentiation] GO:0030335 [positive regulation of cell migration] GO:0030889 [negative regulation of B cell proliferation] GO:0031175 [neuron projection development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031625 [ubiquitin protein ligase binding] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0031668 [cellular response to extracellular stimulus] GO:0031966 [mitochondrial membrane] GO:0032403 [protein complex binding] GO:0032868 [response to insulin] GO:0033003 [regulation of mast cell activation] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034605 [cellular response to heat] GO:0034666 [integrin alpha2-beta1 complex] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042327 [positive regulation of phosphorylation] GO:0042493 [response to drug] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042629 [mast cell granule] GO:0043015 [gamma-tubulin binding] GO:0043200 [response to amino acid] GO:0043208 [glycosphingolipid binding] GO:0043304 [regulation of mast cell degranulation] GO:0043407 [negative regulation of MAP kinase activity] GO:0043434 [response to peptide hormone] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045646 [regulation of erythrocyte differentiation] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048678 [response to axon injury] GO:0050663 [cytokine secretion] GO:0050707 [regulation of cytokine secretion] GO:0050727 [regulation of inflammatory response] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050777 [negative regulation of immune response] GO:0050853 [B cell receptor signaling pathway] GO:0050855 [regulation of B cell receptor signaling pathway] GO:0050861 [positive regulation of B cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051272 [positive regulation of cellular component movement] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0060252 [positive regulation of glial cell proliferation] GO:0060369 [positive regulation of Fc receptor mediated stimulatory signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070062 [extracellular exosome] GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070447 [positive regulation of oligodendrocyte progenitor proliferation] GO:0070667 [negative regulation of mast cell proliferation] GO:0070668 [positive regulation of mast cell proliferation] GO:0071300 [cellular response to retinoic acid] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090025 [regulation of monocyte chemotaxis] GO:0090330 [regulation of platelet aggregation] GO:0097028 [dendritic cell differentiation] GO:1902532 [negative regulation of intracellular signal transduction] GO:2000670 [positive regulation of dendritic cell apoptotic process]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001782 [B cell homeostasis] GO:0001817 [regulation of cytokine production] GO:0001932 [regulation of protein phosphorylation] GO:0001933 [negative regulation of protein phosphorylation] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002431 [Fc receptor mediated stimulatory signaling pathway] GO:0002513 [tolerance induction to self antigen] GO:0002576 [platelet degranulation] GO:0002768 [immune response-regulating cell surface receptor signaling pathway] GO:0002774 [Fc receptor mediated inhibitory signaling pathway] GO:0002902 [regulation of B cell apoptotic process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone] GO:0010976 [positive regulation of neuron projection development] GO:0016032 [viral process] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0030168 [platelet activation] GO:0030218 [erythrocyte differentiation] GO:0030889 [negative regulation of B cell proliferation] GO:0031175 [neuron projection development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0033003 [regulation of mast cell activation] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0043304 [regulation of mast cell degranulation] GO:0043407 [negative regulation of MAP kinase activity] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045646 [regulation of erythrocyte differentiation] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050777 [negative regulation of immune response] GO:0050855 [regulation of B cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051272 [positive regulation of cellular component movement] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070062 [extracellular exosome] GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070667 [negative regulation of mast cell proliferation] GO:0070668 [positive regulation of mast cell proliferation] GO:0071300 [cellular response to retinoic acid] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090025 [regulation of monocyte chemotaxis] GO:0090330 [regulation of platelet aggregation] GO:0097028 [dendritic cell differentiation] GO:1902532 [negative regulation of intracellular signal transduction] GO:2000670 [positive regulation of dendritic cell apoptotic process]