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Malignant lymphoma and cases of cholangiocellular and gastric cancers showed moderate membranous and cytoplasmic positivity. Remaining malignancies were weakly stained or negative.
Malignant lymphomas and several cases of malignant gliomas, lung, gastric, urothelial, pancreatic, liver, ovarian and colorectal cancers showed moderate to strong cytoplasmic positivity. Other malignancies were mainly negative.
GENE INFORMATION
Gene name
LYN (HGNC Symbol)
Synonyms
JTK8
Description
LYN proto-oncogene, Src family tyrosine kinase (HGNC Symbol)
Entrez gene summary
This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001782 [B cell homeostasis] GO:0001817 [regulation of cytokine production] GO:0001932 [regulation of protein phosphorylation] GO:0001933 [negative regulation of protein phosphorylation] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002431 [Fc receptor mediated stimulatory signaling pathway] GO:0002513 [tolerance induction to self antigen] GO:0002553 [histamine secretion by mast cell] GO:0002576 [platelet degranulation] GO:0002762 [negative regulation of myeloid leukocyte differentiation] GO:0002768 [immune response-regulating cell surface receptor signaling pathway] GO:0002774 [Fc receptor mediated inhibitory signaling pathway] GO:0002902 [regulation of B cell apoptotic process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005161 [platelet-derived growth factor receptor binding] GO:0005178 [integrin binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005758 [mitochondrial intermembrane space] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005913 [cell-cell adherens junction] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0006991 [response to sterol depletion] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009636 [response to toxic substance] GO:0009725 [response to hormone] GO:0009743 [response to carbohydrate] GO:0010976 [positive regulation of neuron projection development] GO:0014003 [oligodendrocyte development] GO:0014069 [postsynaptic density] GO:0014070 [response to organic cyclic compound] GO:0016020 [membrane] GO:0016032 [viral process] GO:0017124 [SH3 domain binding] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0030061 [mitochondrial crista] GO:0030097 [hemopoiesis] GO:0030168 [platelet activation] GO:0030218 [erythrocyte differentiation] GO:0030335 [positive regulation of cell migration] GO:0030889 [negative regulation of B cell proliferation] GO:0031175 [neuron projection development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031625 [ubiquitin protein ligase binding] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0031668 [cellular response to extracellular stimulus] GO:0031966 [mitochondrial membrane] GO:0032403 [protein complex binding] GO:0032868 [response to insulin] GO:0033003 [regulation of mast cell activation] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0034605 [cellular response to heat] GO:0034666 [integrin alpha2-beta1 complex] GO:0035556 [intracellular signal transduction] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042327 [positive regulation of phosphorylation] GO:0042493 [response to drug] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0042629 [mast cell granule] GO:0043015 [gamma-tubulin binding] GO:0043200 [response to amino acid] GO:0043208 [glycosphingolipid binding] GO:0043304 [regulation of mast cell degranulation] GO:0043407 [negative regulation of MAP kinase activity] GO:0043434 [response to peptide hormone] GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045646 [regulation of erythrocyte differentiation] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0048678 [response to axon injury] GO:0050663 [cytokine secretion] GO:0050707 [regulation of cytokine secretion] GO:0050727 [regulation of inflammatory response] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050777 [negative regulation of immune response] GO:0050853 [B cell receptor signaling pathway] GO:0050855 [regulation of B cell receptor signaling pathway] GO:0050861 [positive regulation of B cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051219 [phosphoprotein binding] GO:0051272 [positive regulation of cellular component movement] GO:0051279 [regulation of release of sequestered calcium ion into cytosol] GO:0060252 [positive regulation of glial cell proliferation] GO:0060369 [positive regulation of Fc receptor mediated stimulatory signaling pathway] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070062 [extracellular exosome] GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070447 [positive regulation of oligodendrocyte progenitor proliferation] GO:0070667 [negative regulation of mast cell proliferation] GO:0070668 [positive regulation of mast cell proliferation] GO:0071300 [cellular response to retinoic acid] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090025 [regulation of monocyte chemotaxis] GO:0090330 [regulation of platelet aggregation] GO:0097028 [dendritic cell differentiation] GO:1902532 [negative regulation of intracellular signal transduction] GO:2000670 [positive regulation of dendritic cell apoptotic process]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001782 [B cell homeostasis] GO:0001817 [regulation of cytokine production] GO:0001932 [regulation of protein phosphorylation] GO:0001933 [negative regulation of protein phosphorylation] GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0002431 [Fc receptor mediated stimulatory signaling pathway] GO:0002513 [tolerance induction to self antigen] GO:0002576 [platelet degranulation] GO:0002768 [immune response-regulating cell surface receptor signaling pathway] GO:0002774 [Fc receptor mediated inhibitory signaling pathway] GO:0002902 [regulation of B cell apoptotic process] GO:0004672 [protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0004715 [non-membrane spanning protein tyrosine kinase activity] GO:0004716 [receptor signaling protein tyrosine kinase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006974 [cellular response to DNA damage stimulus] GO:0007165 [signal transduction] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007411 [axon guidance] GO:0007596 [blood coagulation] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0009725 [response to hormone] GO:0010976 [positive regulation of neuron projection development] GO:0016032 [viral process] GO:0018108 [peptidyl-tyrosine phosphorylation] GO:0019899 [enzyme binding] GO:0023014 [signal transduction by protein phosphorylation] GO:0030168 [platelet activation] GO:0030218 [erythrocyte differentiation] GO:0030889 [negative regulation of B cell proliferation] GO:0031175 [neuron projection development] GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane] GO:0031295 [T cell costimulation] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0033003 [regulation of mast cell activation] GO:0033628 [regulation of cell adhesion mediated by integrin] GO:0034136 [negative regulation of toll-like receptor 2 signaling pathway] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0038083 [peptidyl-tyrosine autophosphorylation] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis] GO:0042531 [positive regulation of tyrosine phosphorylation of STAT protein] GO:0043304 [regulation of mast cell degranulation] GO:0043407 [negative regulation of MAP kinase activity] GO:0044325 [ion channel binding] GO:0045087 [innate immune response] GO:0045121 [membrane raft] GO:0045646 [regulation of erythrocyte differentiation] GO:0046777 [protein autophosphorylation] GO:0048013 [ephrin receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050777 [negative regulation of immune response] GO:0050855 [regulation of B cell receptor signaling pathway] GO:0050900 [leukocyte migration] GO:0051272 [positive regulation of cellular component movement] GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway] GO:0070062 [extracellular exosome] GO:0070304 [positive regulation of stress-activated protein kinase signaling cascade] GO:0070372 [regulation of ERK1 and ERK2 cascade] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:0070667 [negative regulation of mast cell proliferation] GO:0070668 [positive regulation of mast cell proliferation] GO:0071300 [cellular response to retinoic acid] GO:0071375 [cellular response to peptide hormone stimulus] GO:0090025 [regulation of monocyte chemotaxis] GO:0090330 [regulation of platelet aggregation] GO:0097028 [dendritic cell differentiation] GO:1902532 [negative regulation of intracellular signal transduction] GO:2000670 [positive regulation of dendritic cell apoptotic process]