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ASIC5

GENERAL INFORMATION

Gene name

 ASIC5

Gene description

 Acid sensing (proton gated) ion channel family member 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, small intestine)
GTEx:Not detected
FANTOM5:Tissue enhanced (small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in a few tissues, including luminal membranous expression in intestinal tract

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA014903 , HPA029444
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION

Gene name

 ASIC5 (HGNC Symbol)

Synonyms

 ACCN5, HINAC, INAC

Description

 Acid sensing (proton gated) ion channel family member 5 (HGNC Symbol)

Entrez gene summary

 This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q32.1

Chromosome location (bp)

 155829729 - 155866273

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000256394 (version 83.38)

Entrez gene

 51802

UniProt

 Q9NY37 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NY37

Antibodypedia

 ASIC5 antibodies

PROTEIN BROWSER
ASIC5-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASIC5-001
ENSP00000442477
ENST00000537611
Q9NY37 [Direct mapping]
Acid-sensing ion channel 5
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
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GO:0005272 [sodium channel activity]
GO:0005886 [plasma membrane]
GO:0006814 [sodium ion transport]
GO:0015252 [hydrogen ion channel activity]
GO:0015280 [ligand-gated sodium channel activity]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
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 505 aa
57.5 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.