Expression of COMMD3-BMI1 in cancer - Summary - The Human Protein Atlas

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COMMD3-BMI1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	COMMD3-BMI1
Gene description	COMMD3-BMI1 readthrough
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in a few tissues, including testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, targets protein from more than one gene. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 2 antibodies. HPA030472 , HPA036584
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030472	HPA036584

GENE INFORMATION
Gene name	COMMD3-BMI1
Synonyms
Description	COMMD3-BMI1 readthrough (HGNC Symbol)
Entrez gene summary	This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Chromosome	10
Cytoband	p12.2
Chromosome location (bp)	22316388 - 22329542
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000269897 (version 83.38)
Entrez gene	100532731
UniProt
neXtProt
Antibodypedia	COMMD3-BMI1 antibodies

PROTEIN BROWSER

COMMD3-BMI1-001	COMMD3-BMI1-004	COMMD3-BMI1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COMMD3-BMI1-001 ENSP00000473391 ENST00000602390	R4GMX3 [Direct mapping] Protein COMMD3-BMI1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0046872 [metal ion binding] Show all	469 aa 53.3 kDa	No	0
COMMD3-BMI1-004 ENSP00000473382 ENST00000475460	R4GMW6 [Direct mapping] Protein COMMD3-BMI1 Show all	Predicted intracellular proteins Show all		159 aa 18.1 kDa	No	0
COMMD3-BMI1-005 ENSP00000473495 ENST00000489125	R4GN54 [Direct mapping] Protein COMMD3-BMI1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		110 aa 12.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.