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PKD1L3

GENERAL INFORMATION

Gene name

 PKD1L3

Gene description

 Polycystic kidney disease 1-like 3

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Not detected

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected
0.0500m1.01.52.02.53.03.54.04.5FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PKD1L3

Synonyms

Description

 Polycystic kidney disease 1-like 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the polycystin protein family. The encoded protein contains 11 transmembrane domains, a latrophilin/CL-1-like GPCR proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. This protein may function as a component of cation channel pores.[provided by RefSeq, Apr 2009]

Chromosome

 16

Cytoband

 q22.2

Chromosome location (bp)

 71929538 - 71999978

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000277481 (version 83.38)

Entrez gene

 342372

UniProt

 Q7Z443 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z443

Antibodypedia

 PKD1L3 antibodies

PROTEIN BROWSER
PKD1L3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PKD1L3-001
ENSP00000480090
ENST00000620267
Q7Z443 [Direct mapping]
Polycystic kidney disease protein 1-like 3
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
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GO:0001581 [detection of chemical stimulus involved in sensory perception of sour taste]
GO:0001822 [kidney development]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0008324 [cation transmembrane transporter activity]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
GO:0033040 [sour taste receptor activity]
GO:0034703 [cation channel complex]
GO:0043235 [receptor complex]
GO:0050915 [sensory perception of sour taste]
GO:0070062 [extracellular exosome]
GO:0070588 [calcium ion transmembrane transport]
GO:0071468 [cellular response to acidic pH]
GO:0098655 [cation transmembrane transport]
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 1732 aa
195.9 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.