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The Pathology Atlas contains mRNA and protein expression data for the most common forms of human cancer. Correlation analyses based on mRNA expression levels of human genes in cancer tissue and the clinical outcome for almost 8000 corresponding cancer patients is presented in a gene-centric manner, and includes more than 18000 Kaplan-Meier plots with high significance (p<0.001). In addition, immunohistochemistry (IHC) analysis using a tissue microarray (TMA)-based analysis of the corresponding proteins in patients with the respective cancer types is presented for a majority of the protein-coding genes. More than 5 million IHC cancer tissue images are included in the atlas, showing protein expression levels for individual tumors of each cancer type.
More information is available in the About sections and on the Cancer Proteome pages.
The data in the Pathology Atlas is based on the integration of publicly available data from The Cancer Genome Atlas (TCGA) and data generated within the framework of the Human Protein Atlas (HPA).
Example proteins in the pathology atlas
Below are three examples of genes where the mRNA expression level correlates with patient survival. Relative high expression of TIMELESS and CDK1 is associated with poor prognosis in melanoma and pancreatic cancer respectively, whereas relative high expression of FOXA1 correlates with a favorable prognosis in urinary bladder cancer.
High expression
Low expression
Kaplan-Meier plot
TIMELESS Timeless circadian clock
The protein encoded by this gene is highly conserved and is invloved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance or telomere length, and epithlial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop.
CDK1 Cyclin-dependent kinase 1
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M.
