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ABLIM1

GENERAL INFORMATION

Gene name

 ABLIM1

Gene description

 Actin binding LIM protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA038951 , HPA038952
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038951
HPA038952

GENE INFORMATION

Gene name

 ABLIM1 (HGNC Symbol)

Synonyms

 ABLIM, LIMAB1, limatin

Description

 Actin binding LIM protein 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q25.3

Chromosome location (bp)

 114431113 - 114685003

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000099204 (version 83.38)

Entrez gene

 3983

UniProt

 O14639 (UniProt - Evidence at protein level)

neXtProt

 NX_O14639

Antibodypedia

 ABLIM1 antibodies

PROTEIN BROWSER
ABLIM1-001
ABLIM1-002
ABLIM1-005
ABLIM1-009
ABLIM1-010
ABLIM1-011
ABLIM1-012
ABLIM1-201
ABLIM1-202
ABLIM1-203

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABLIM1-001
ENSP00000277895
ENST00000277895
O14639 [Direct mapping]
Actin-binding LIM protein 1
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007411 [axon guidance]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0015629 [actin cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0042384 [cilium assembly]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0097481 [neuronal postsynaptic density]
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 778 aa
87.7 kDa 		No 0
ABLIM1-002
ENSP00000376682
ENST00000392955
O14639 [Direct mapping]
Actin-binding LIM protein 1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007411 [axon guidance]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0015629 [actin cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0042384 [cilium assembly]
Show all
 718 aa
81.1 kDa 		No 0
ABLIM1-005
ENSP00000358260
ENST00000369256
O14639 [Direct mapping]
Actin-binding LIM protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007411 [axon guidance]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0015629 [actin cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0042384 [cilium assembly]
Show all
 748 aa
84.6 kDa 		No 0
ABLIM1-009
ENSP00000376679
ENST00000392952
O14639 [Direct mapping]
Actin-binding LIM protein 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007411 [axon guidance]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0015629 [actin cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0042384 [cilium assembly]
Show all
 455 aa
52.1 kDa 		No 0
ABLIM1-010
ENSP00000358257
ENST00000369253
O14639 [Direct mapping]
Actin-binding LIM protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001725 [stress fiber]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0007010 [cytoskeleton organization]
GO:0007411 [axon guidance]
GO:0007601 [visual perception]
GO:0008270 [zinc ion binding]
GO:0009887 [organ morphogenesis]
GO:0015629 [actin cytoskeleton]
GO:0030027 [lamellipodium]
GO:0030032 [lamellipodium assembly]
GO:0042384 [cilium assembly]
Show all
 401 aa
46.1 kDa 		No 0
ABLIM1-011
ENSP00000400934
ENST00000428430
F6XFR5 [Direct mapping]
Actin-binding LIM protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 173 aa
19.8 kDa 		No 0
ABLIM1-012
ENSP00000414154
ENST00000440467
H0Y7N6 [Direct mapping]
Actin-binding LIM protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 172 aa
19.6 kDa 		No 0
ABLIM1-201
ENSP00000358256
ENST00000369252
A0A0A0MRL6 [Direct mapping]
Actin-binding LIM protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0007010 [cytoskeleton organization]
GO:0008270 [zinc ion binding]
Show all
 746 aa
84.4 kDa 		No 0
ABLIM1-202
ENSP00000358270
ENST00000369266
J3QSX6 [Direct mapping]
Actin-binding LIM protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0007010 [cytoskeleton organization]
Show all
 401 aa
46.1 kDa 		No 0
ABLIM1-203
ENSP00000433629
ENST00000533213
F8W8M4 [Direct mapping]
Actin-binding LIM protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0007010 [cytoskeleton organization]
GO:0008270 [zinc ion binding]
Show all
 718 aa
81.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.