Cell atlas - BNIP3L - The Human Protein Atlas

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BNIP3L

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria
	Nuclear speckles

Human cell
	Mitochondria
	Nucleoplasm

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GENERAL INFORMATION
Gene name	BNIP3L
Gene description	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Protein class	Cancer-related genes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the mitochondria. In addition localized to the nuclear speckles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (approved)
Additional location	In addition localized to the Nuclear speckles (supported)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 2 antibodies. HPA015652 , CAB025371
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the mitochondria. In addition localized to the nuclear speckles.

Main location

Mitochondria (approved)

Additional location

Nuclear speckles (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA015652	A-431	Nuclear speckles
	HPA015652	A-431	Mitochondria
	HPA015652	U-2 OS	Nuclear speckles
	HPA015652	U-2 OS	Mitochondria
	HPA015652	U-251 MG	Nuclear speckles
	HPA015652	U-251 MG	Mitochondria
	CAB025371	A-431	Mitochondria
	CAB025371	U-2 OS	Mitochondria	Intensity

GENE INFORMATION
Gene name	BNIP3L (HGNC Symbol)
Synonyms	BNIP3a, Nix
Description	BCL2/adenovirus E1B 19kDa interacting protein 3-like (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	26382898 - 26505636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104765 (version 83.38)
Entrez gene	665
UniProt	O60238 (UniProt - Evidence at protein level)
neXtProt	NX_O60238
Antibodypedia	BNIP3L antibodies

PROTEIN BROWSER

BNIP3L-001	BNIP3L-002	BNIP3L-004	BNIP3L-006	BNIP3L-007	BNIP3L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNIP3L-001 ENSP00000370003 ENST00000380629	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Q6IBV1 [Target identity:100%; Query identity:100%] BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNIP3L protein; cDNA FLJ75547, highly similar to Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L), mRNA Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] GO:1903146 [regulation of mitophagy] GO:1903214 [regulation of protein targeting to mitochondrion] Show all	219 aa 23.9 kDa	No	1
BNIP3L-002 ENSP00000429698 ENST00000523515	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-004 ENSP00000429851 ENST00000518611	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-006 ENSP00000428597 ENST00000520409	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-007 ENSP00000429171 ENST00000523949	H0YBC7 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	185 aa 20.1 kDa	No	1
BNIP3L-201 ENSP00000479522 ENST00000620910	A0A087WVL5 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	229 aa 25.3 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.