Expression of BNIP3L in cancer - Summary - The Human Protein Atlas

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BNIP3L

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BNIP3L
Gene description	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Protein class	Cancer-related genes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression, which often had a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA015652 , CAB025371
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and thyroid cancer (unfavourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015652	CAB025371

GENE INFORMATION
Gene name	BNIP3L (HGNC Symbol)
Synonyms	BNIP3a, Nix
Description	BCL2/adenovirus E1B 19kDa interacting protein 3-like (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	26382898 - 26505636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104765 (version 83.38)
Entrez gene	665
UniProt	O60238 (UniProt - Evidence at protein level)
neXtProt	NX_O60238
Antibodypedia	BNIP3L antibodies

PROTEIN BROWSER

BNIP3L-001	BNIP3L-002	BNIP3L-004	BNIP3L-006	BNIP3L-007	BNIP3L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNIP3L-001 ENSP00000370003 ENST00000380629	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Q6IBV1 [Target identity:100%; Query identity:100%] BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNIP3L protein; cDNA FLJ75547, highly similar to Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L), mRNA Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] GO:1903146 [regulation of mitophagy] GO:1903214 [regulation of protein targeting to mitochondrion] Show all	219 aa 23.9 kDa	No	1
BNIP3L-002 ENSP00000429698 ENST00000523515	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-004 ENSP00000429851 ENST00000518611	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-006 ENSP00000428597 ENST00000520409	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-007 ENSP00000429171 ENST00000523949	H0YBC7 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	185 aa 20.1 kDa	No	1
BNIP3L-201 ENSP00000479522 ENST00000620910	A0A087WVL5 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	229 aa 25.3 kDa	No	1

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