Tissue expression of BNIP3L - Summary - The Human Protein Atlas

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BNIP3L

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	BNIP3L
Gene description	BCL2/adenovirus E1B 19kDa interacting protein 3-like
Protein class	Cancer-related genes Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression, which often had a granular pattern.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA015652 , CAB025371
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	BNIP3L (HGNC Symbol)
Synonyms	BNIP3a, Nix
Description	BCL2/adenovirus E1B 19kDa interacting protein 3-like (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to the pro-apoptotic subfamily within the Bcl-2 family of proteins. The encoded protein binds to Bcl-2 and possesses the BH3 domain. The protein directly targets mitochondria and causes apoptotic changes, including loss of membrane potential and the release of cytochrome c. [provided by RefSeq, Feb 2015]
Chromosome	8
Cytoband	p21.2
Chromosome location (bp)	26382898 - 26505636
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104765 (version 83.38)
Entrez gene	665
UniProt	O60238 (UniProt - Evidence at protein level)
neXtProt	NX_O60238
Antibodypedia	BNIP3L antibodies

PROTEIN BROWSER

BNIP3L-001	BNIP3L-002	BNIP3L-004	BNIP3L-006	BNIP3L-007	BNIP3L-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BNIP3L-001 ENSP00000370003 ENST00000380629	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Q6IBV1 [Target identity:100%; Query identity:100%] BCL2/adenovirus E1B 19kDa interacting protein 3-like; BNIP3L protein; cDNA FLJ75547, highly similar to Homo sapiens BCL2/adenovirus E1B 19kDa interacting protein 3-like (BNIP3L), mRNA Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] GO:1903146 [regulation of mitophagy] GO:1903214 [regulation of protein targeting to mitochondrion] Show all	219 aa 23.9 kDa	No	1
BNIP3L-002 ENSP00000429698 ENST00000523515	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-004 ENSP00000429851 ENST00000518611	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-006 ENSP00000428597 ENST00000520409	O60238 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005521 [lamin binding] GO:0005635 [nuclear envelope] GO:0005739 [mitochondrion] GO:0005740 [mitochondrial envelope] GO:0005741 [mitochondrial outer membrane] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0031224 [intrinsic component of membrane] GO:0035694 [mitochondrial protein catabolic process] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0051607 [defense response to virus] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	179 aa 19.6 kDa	No	1
BNIP3L-007 ENSP00000429171 ENST00000523949	H0YBC7 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	185 aa 20.1 kDa	No	1
BNIP3L-201 ENSP00000479522 ENST00000620910	A0A087WVL5 [Direct mapping] BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005740 [mitochondrial envelope] GO:0016021 [integral component of membrane] GO:0043065 [positive regulation of apoptotic process] GO:0097345 [mitochondrial outer membrane permeabilization] Show all	229 aa 25.3 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.